7OS4

Crystal structure of mouse CARM1 in complex with histone H3_13-31 K18

Summary for 7OS4

• Entry DOI: 10.2210/pdb7os4/pdb
• Descriptor: Histone-arginine methyltransferase CARM1, Histone H3.1, (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, ... (4 entities in total)
• Functional Keywords: protein arginine n-methyltransferase, prmt, carm1, transition state mimics, transcription
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 8
• Total formula weight: 176981.17

Authors

Marechal, N.,Cura, V.,Troffer-Charlier, N.,Bonnefond, L.,Cavarelli, J. (deposition date: 2021-06-07, release date: 2021-10-27, Last modification date: 2024-01-31)

• Primary citation: Zhang, Y.,Marechal, N.,van Haren, M.J.,Troffer-Charlier, N.,Cura, V.,Cavarelli, J.,Martin, N.I.; Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.; Chembiochem, 22:3469-3476, 2021; PubMed: 34569136; DOI: 10.1002/cbic.202100506

Experimental method

X-RAY DIFFRACTION (2.54 Å)