5K8X

Crystal structure of mouse CARM1 in complex with inhibitor U3

Summary for 5K8X

DescriptorHistone-arginine methyltransferase CARM1, [[[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]amino]-azanyl-methylidene]azanium, 1,2-ETHANEDIOL, ... (9 entities in total)
Functional Keywordsprotein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
Biological sourceMus musculus (Mouse)
Cellular locationNucleus Q9WVG6
Total number of polymer chains4
Total molecular weight167382.31
Authors
Primary citation
Cura, V.,Marechal, N.,Mailliot, J.,Troffer-Charlier, N.,Wurtz, J.M.,Bonnefond, L.,Cavarelli, J.
Crystal structure of mouse CARM1 in complex with inhibitor U3
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.991 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.212200.5%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report