5K8X
Crystal structure of mouse CARM1 in complex with inhibitor U3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Histone-arginine methyltransferase CARM1 | polymer | 361 | 40850.5 | 4 | UniProt (Q9WVG6) Pfam (PF06325) In PDB | Mus musculus (Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | D, A, B, C | [[[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]amino]-azanyl-methylidene]azanium | non-polymer | 335.3 | 4 | Chemie (6ZH) | |||
| 3 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 4 | A, C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) | |||
| 5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 6 | A | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL | non-polymer | 370.4 | 1 | Chemie (PE8) | |||
| 7 | C, D, B | 1,2-DIMETHOXYETHANE | non-polymer | 90.1 | 6 | Chemie (DXE) | |||
| 8 | C | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | non-polymer | 134.2 | 1 | Chemie (M2M) | |||
| 9 | water | water | 18.0 | 834 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 130 - 487 (UniProt: Q9WVG6)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | expression tag |
| His 128 | - | expression tag |
| Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 163401.8 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 3980.5 | |
| All* | Total formula weight | 167382.3 |
