5K8X
Crystal structure of mouse CARM1 in complex with inhibitor U3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 6ZH A 501 |
| Chain | Residue |
| A | TYR150 |
| A | GLU244 |
| A | GLU258 |
| A | MET260 |
| A | GLU267 |
| A | MET269 |
| A | SER272 |
| A | PG4508 |
| A | HOH624 |
| A | HOH663 |
| A | HOH686 |
| A | PHE151 |
| A | TYR154 |
| A | GLY193 |
| A | GLU215 |
| A | ALA216 |
| A | GLY241 |
| A | LYS242 |
| A | VAL243 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | TRP404 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | LEU413 |
| A | THR414 |
| A | TYR417 |
| A | HOH678 |
| A | HOH771 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | PHE153 |
| A | GLN159 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | GLU144 |
| A | LYS242 |
| A | HOH625 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 506 |
| Chain | Residue |
| A | SER283 |
| A | GLY398 |
| A | SER399 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 507 |
| Chain | Residue |
| A | LYS277 |
| A | LEU280 |
| A | PRO282 |
| A | HOH608 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 A 508 |
| Chain | Residue |
| A | PHE153 |
| A | TYR262 |
| A | GLU267 |
| A | HIS415 |
| A | TRP416 |
| A | 6ZH501 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue PE8 A 509 |
| Chain | Residue |
| A | GLN456 |
| A | LYS463 |
| A | HOH631 |
| B | SER136 |
| B | GLU244 |
| B | GLU245 |
| B | SER247 |
| B | GLN251 |
| B | TYR279 |
| B | HOH670 |
| site_id | AD1 |
| Number of Residues | 18 |
| Details | binding site for residue 6ZH B 501 |
| Chain | Residue |
| B | TYR150 |
| B | PHE151 |
| B | TYR154 |
| B | GLY193 |
| B | GLU215 |
| B | ALA216 |
| B | GLY241 |
| B | LYS242 |
| B | VAL243 |
| B | GLU244 |
| B | GLU258 |
| B | GLU267 |
| B | MET269 |
| B | SER272 |
| B | HOH611 |
| B | HOH645 |
| B | HOH659 |
| B | HOH681 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | ALA147 |
| B | LYS242 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | ASP458 |
| B | HOH607 |
| C | LEU178 |
| C | GLN205 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | HIS415 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue DXE B 506 |
| Chain | Residue |
| B | GLU267 |
| site_id | AD6 |
| Number of Residues | 18 |
| Details | binding site for residue 6ZH C 501 |
| Chain | Residue |
| C | TYR150 |
| C | PHE151 |
| C | TYR154 |
| C | GLY193 |
| C | GLU215 |
| C | ALA216 |
| C | GLY241 |
| C | LYS242 |
| C | VAL243 |
| C | GLU244 |
| C | GLU258 |
| C | MET260 |
| C | GLU267 |
| C | MET269 |
| C | SER272 |
| C | HOH614 |
| C | HOH674 |
| C | HOH688 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| C | THR410 |
| C | HOH761 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue PEG C 504 |
| Chain | Residue |
| C | GLY284 |
| C | GLY398 |
| C | SER399 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue PEG C 505 |
| Chain | Residue |
| C | ASP333 |
| C | GLN424 |
| C | HOH661 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue PEG C 506 |
| Chain | Residue |
| C | TRP404 |
| C | HOH625 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue DXE C 507 |
| Chain | Residue |
| C | LYS277 |
| C | LEU280 |
| C | PRO282 |
| C | LEU361 |
| C | HOH706 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue DXE C 508 |
| Chain | Residue |
| B | PHE428 |
| C | GLN165 |
| D | GLN316 |
| D | EDO503 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue DXE C 509 |
| Chain | Residue |
| C | PHE153 |
| C | GLN159 |
| D | ASN472 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue M2M C 510 |
| Chain | Residue |
| C | TYR262 |
| C | GLU267 |
| site_id | AE6 |
| Number of Residues | 18 |
| Details | binding site for residue 6ZH D 501 |
| Chain | Residue |
| D | TYR150 |
| D | PHE151 |
| D | TYR154 |
| D | GLY193 |
| D | GLU215 |
| D | ALA216 |
| D | GLY241 |
| D | LYS242 |
| D | VAL243 |
| D | GLU244 |
| D | GLU258 |
| D | MET260 |
| D | GLU267 |
| D | MET269 |
| D | SER272 |
| D | HOH619 |
| D | HOH663 |
| D | HOH682 |
| site_id | AE7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 502 |
| Chain | Residue |
| D | TRP404 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| C | DXE508 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 505 |
| Chain | Residue |
| D | PRO409 |
| D | THR410 |
| D | GLU411 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue DXE D 507 |
| Chain | Residue |
| D | ASN162 |
| D | HIS415 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17882261 |
| Chain | Residue | Details |
| A | GLN160 | |
| B | GLU215 | |
| B | GLU244 | |
| B | SER272 | |
| C | GLN160 | |
| C | ARG169 | |
| C | GLY193 | |
| C | GLU215 | |
| C | GLU244 | |
| C | SER272 | |
| D | GLN160 | |
| A | ARG169 | |
| D | ARG169 | |
| D | GLY193 | |
| D | GLU215 | |
| D | GLU244 | |
| D | SER272 | |
| A | GLY193 | |
| A | GLU215 | |
| A | GLU244 | |
| A | SER272 | |
| B | GLN160 | |
| B | ARG169 | |
| B | GLY193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
| Chain | Residue | Details |
| A | SER217 | |
| B | SER217 | |
| C | SER217 | |
| D | SER217 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 |
| Chain | Residue | Details |
| A | LYS228 | |
| B | LYS228 | |
| C | LYS228 | |
| D | LYS228 |
