5K8X

Crystal structure of mouse CARM1 in complex with inhibitor U3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0018216	biological_process	peptidyl-arginine methylation
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue 6ZH A 501

Chain	Residue
A	TYR150
A	GLU244
A	GLU258
A	MET260
A	GLU267
A	MET269
A	SER272
A	PG4508
A	HOH624
A	HOH663
A	HOH686
A	PHE151
A	TYR154
A	GLY193
A	GLU215
A	ALA216
A	GLY241
A	LYS242
A	VAL243

---

site_id	AC2
Number of Residues	1
Details	binding site for residue EDO A 502

Chain	Residue
A	TRP404

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 503

Chain	Residue
A	LEU413
A	THR414
A	TYR417
A	HOH678
A	HOH771

---

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 504

Chain	Residue
A	PHE153
A	GLN159

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 505

Chain	Residue
A	GLU144
A	LYS242
A	HOH625

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PEG A 506

Chain	Residue
A	SER283
A	GLY398
A	SER399

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PEG A 507

Chain	Residue
A	LYS277
A	LEU280
A	PRO282
A	HOH608

---

site_id	AC8
Number of Residues	6
Details	binding site for residue PG4 A 508

Chain	Residue
A	PHE153
A	TYR262
A	GLU267
A	HIS415
A	TRP416
A	6ZH501

---

site_id	AC9
Number of Residues	10
Details	binding site for residue PE8 A 509

Chain	Residue
A	GLN456
A	LYS463
A	HOH631
B	SER136
B	GLU244
B	GLU245
B	SER247
B	GLN251
B	TYR279
B	HOH670

---

site_id	AD1
Number of Residues	18
Details	binding site for residue 6ZH B 501

Chain	Residue
B	TYR150
B	PHE151
B	TYR154
B	GLY193
B	GLU215
B	ALA216
B	GLY241
B	LYS242
B	VAL243
B	GLU244
B	GLU258
B	GLU267
B	MET269
B	SER272
B	HOH611
B	HOH645
B	HOH659
B	HOH681

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO B 502

Chain	Residue
B	ALA147
B	LYS242

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO B 503

Chain	Residue
B	ASP458
B	HOH607
C	LEU178
C	GLN205

---

site_id	AD4
Number of Residues	1
Details	binding site for residue EDO B 504

Chain	Residue
B	HIS415

---

site_id	AD5
Number of Residues	1
Details	binding site for residue DXE B 506

Chain	Residue
B	GLU267

---

site_id	AD6
Number of Residues	18
Details	binding site for residue 6ZH C 501

Chain	Residue
C	TYR150
C	PHE151
C	TYR154
C	GLY193
C	GLU215
C	ALA216
C	GLY241
C	LYS242
C	VAL243
C	GLU244
C	GLU258
C	MET260
C	GLU267
C	MET269
C	SER272
C	HOH614
C	HOH674
C	HOH688

---

site_id	AD7
Number of Residues	2
Details	binding site for residue EDO C 502

Chain	Residue
C	THR410
C	HOH761

---

site_id	AD8
Number of Residues	3
Details	binding site for residue PEG C 504

Chain	Residue
C	GLY284
C	GLY398
C	SER399

---

site_id	AD9
Number of Residues	3
Details	binding site for residue PEG C 505

Chain	Residue
C	ASP333
C	GLN424
C	HOH661

---

site_id	AE1
Number of Residues	2
Details	binding site for residue PEG C 506

Chain	Residue
C	TRP404
C	HOH625

---

site_id	AE2
Number of Residues	5
Details	binding site for residue DXE C 507

Chain	Residue
C	LYS277
C	LEU280
C	PRO282
C	LEU361
C	HOH706

---

site_id	AE3
Number of Residues	4
Details	binding site for residue DXE C 508

Chain	Residue
B	PHE428
C	GLN165
D	GLN316
D	EDO503

---

site_id	AE4
Number of Residues	3
Details	binding site for residue DXE C 509

Chain	Residue
C	PHE153
C	GLN159
D	ASN472

---

site_id	AE5
Number of Residues	2
Details	binding site for residue M2M C 510

Chain	Residue
C	TYR262
C	GLU267

---

site_id	AE6
Number of Residues	18
Details	binding site for residue 6ZH D 501

Chain	Residue
D	TYR150
D	PHE151
D	TYR154
D	GLY193
D	GLU215
D	ALA216
D	GLY241
D	LYS242
D	VAL243
D	GLU244
D	GLU258
D	MET260
D	GLU267
D	MET269
D	SER272
D	HOH619
D	HOH663
D	HOH682

---

site_id	AE7
Number of Residues	1
Details	binding site for residue EDO D 502

Chain	Residue
D	TRP404

---

site_id	AE8
Number of Residues	1
Details	binding site for residue EDO D 503

Chain	Residue
C	DXE508

---

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO D 505

Chain	Residue
D	PRO409
D	THR410
D	GLU411

---

site_id	AF1
Number of Residues	2
Details	binding site for residue DXE D 507

Chain	Residue
D	ASN162
D	HIS415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1228
Details	Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---