5K8V

Crystal Structure of Mus musculus Protein Arginine Methyltransferase 4 (CARM1 130-487) with CP1

Summary for 5K8V

Entry DOI	10.2210/pdb5k8v/pdb
Descriptor	Histone-arginine methyltransferase CARM1, [[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]-azanyl-methylidene]azanium, 1,2-DIMETHOXYETHANE, ... (7 entities in total)
Functional Keywords	protein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
Biological source	Mus musculus (Mouse)
Cellular location	Nucleus: Q9WVG6
Total number of polymer chains	4
Total formula weight	165884.52
Authors	Cura, V.,Marechal, N.,Mailliot, J.,Troffer-Charlier, N.,Hassenboehler, P.,Wurtz, J.M.,Bonnefond, L.,Cavarelli, J. (deposition date: 2016-05-31, release date: 2016-11-09, Last modification date: 2024-01-10)
Primary citation	Cura, V.,Marechal, N.,Troffer-Charlier, N.,Strub, J.M.,van Haren, M.J.,Martin, N.I.,Cianferani, S.,Bonnefond, L.,Cavarelli, J. Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J., 284:77-96, 2017 Cited by PubMed: 27879050 DOI: 10.1111/febs.13953 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation