5K8V

Crystal Structure of Mus musculus Protein Arginine Methyltransferase 4 (CARM1 130-487) with CP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0018216	biological_process	peptidyl-arginine methylation
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue 6RE A 501

Chain	Residue
A	TYR150
A	GLU244
A	GLU258
A	MET260
A	GLU267
A	MET269
A	SER272
A	HOH642
A	PHE151
A	TYR154
A	GLY193
A	GLU215
A	ALA216
A	GLY241
A	LYS242
A	VAL243

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 504

Chain	Residue
A	PHE153
A	SER158
A	HOH603
B	ASN472

---

site_id	AC3
Number of Residues	1
Details	binding site for residue EDO A 505

Chain	Residue
A	LEU178

---

site_id	AC4
Number of Residues	2
Details	binding site for residue PEG A 507

Chain	Residue
A	ASP345
A	ARG347

---

site_id	AC5
Number of Residues	17
Details	binding site for residue 6RE B 501

Chain	Residue
B	TYR150
B	PHE151
B	TYR154
B	GLY193
B	GLU215
B	ALA216
B	GLY241
B	LYS242
B	VAL243
B	GLU244
B	GLU258
B	MET260
B	GLU267
B	MET269
B	SER272
B	HOH606
B	HOH667

---

site_id	AC6
Number of Residues	8
Details	binding site for residue PG6 B 502

Chain	Residue
A	GLN456
A	LYS463
B	SER136
B	PRO240
B	GLU244
B	GLU245
B	VAL246
B	TYR279

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO B 503

Chain	Residue
B	PHE153

---

site_id	AC8
Number of Residues	1
Details	binding site for residue PEG B 504

Chain	Residue
B	TRP404

---

site_id	AC9
Number of Residues	17
Details	binding site for residue 6RE C 501

Chain	Residue
C	TYR150
C	PHE151
C	TYR154
C	GLY193
C	GLU215
C	ALA216
C	GLY241
C	LYS242
C	VAL243
C	GLU244
C	GLU258
C	PRO259
C	MET260
C	GLU267
C	MET269
C	SER272
C	HOH646

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO C 503

Chain	Residue
C	TRP404
C	HOH636
C	HOH705

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO C 504

Chain	Residue
C	LYS281
C	PRO282
C	LEU361

---

site_id	AD3
Number of Residues	17
Details	binding site for residue 6RE D 501

Chain	Residue
D	TYR150
D	TYR154
D	GLY193
D	GLU215
D	ALA216
D	GLY241
D	LYS242
D	VAL243
D	GLU244
D	GLU258
D	MET260
D	GLU267
D	MET269
D	SER272
D	HOH625
D	HOH661
D	HOH669

---

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO D 503

Chain	Residue
D	ASP393
D	TRP404

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1228
Details	Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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