5TBI

Crystal structure of mouse CARM1 in complex with inhibitor LH1427

Summary for 5TBI

DescriptorHistone-arginine methyltransferase CARM1, 1,2-ETHANEDIOL, 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine, ... (6 entities in total)
Functional Keywordsprotein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
Biological sourceMus musculus (Mouse)
Total number of polymer chains4
Total molecular weight166493.15
Authors
Cura, V.,Marechal, N.,Troffer-Charlier, N.,Halby, L.,Arimondo, P.,Bonnefond, L.,Cavarelli, J. (deposition date: 2016-09-12, release date: 2017-09-20, Last modification date: 2019-04-03)
Primary citation
Halby, L.,Marechal, N.,Pechalrieu, D.,Cura, V.,Franchini, D.M.,Faux, C.,Alby, F.,Troffer-Charlier, N.,Kudithipudi, S.,Jeltsch, A.,Aouadi, W.,Decroly, E.,Guillemot, J.C.,Page, P.,Ferroud, C.,Bonnefond, L.,Guianvarc'h, D.,Cavarelli, J.,Arimondo, P.B.
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Philos.Trans.R.Soc.Lond.B Biol.Sci., 373:-, 2018
PubMed: 29685976 (PDB entries with the same primary citation)
DOI: 10.1098/rstb.2017.0072
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.294 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22520 0.2% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution