5TBI
Crystal structure of mouse CARM1 in complex with inhibitor LH1427
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Histone-arginine methyltransferase CARM1 | polymer | 361 | 40850.5 | 4 | UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528) In PDB | Mus musculus (Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
2 | A, B, C, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
3 | A, C | 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine | non-polymer | 385.4 | 2 | Chemie (SAO) | |||
4 | B | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL | non-polymer | 370.4 | 1 | Chemie (PE8) | |||
5 | B, D | 4-[2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]ethylamino]-1-(methoxymethyl)pyrimidin-2-one | non-polymer | 447.4 | 2 | Chemie (78V) | |||
6 | water | water | 18.0 | 600 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 130 - 487 (UniProt: Q9WVG6)
PDB | External Database | Details |
---|---|---|
Gly 127 | - | expression tag |
His 128 | - | expression tag |
Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 163401.8 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 3091.3 | |
All* | Total formula weight | 166493.2 |