7QTQ
Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.
Summary for 7QTQ
| Entry DOI | 10.2210/pdb7qtq/pdb |
| EMDB information | 14145 |
| Descriptor | Thyroglobulin, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
| Functional Keywords | thyroglobulin, thyroid hormone, iodine, precursor, hormone |
| Biological source | Bos taurus (cattle) |
| Total number of polymer chains | 2 |
| Total formula weight | 612761.51 |
| Authors | Marechal, N.,Weitz, J.C.,Serrano, B.P.,Zhang, X. (deposition date: 2022-01-15, release date: 2022-05-04, Last modification date: 2023-11-15) |
| Primary citation | Marechal, N.,Serrano, B.P.,Zhang, X.,Weitz, C.J. Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin. Nat Commun, 13:2380-2380, 2022 Cited by PubMed Abstract: Thyroid hormones are essential regulators of metabolism, development, and growth. They are formed from pairs of iodinated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa homodimer of the thyroid gland, by an oxidative coupling reaction. Tyrosine pairs that give rise to thyroid hormones have been assigned within the structure of human TG, but the process of hormone formation is poorly understood. Here we report a ~3.3-Å cryo-EM structure of native bovine TG with nascent thyroid hormone formed at one of the predicted hormonogenic sites. Local structural rearrangements provide insight into mechanisms underlying thyroid hormone formation and stabilization. PubMed: 35501346DOI: 10.1038/s41467-022-30082-4 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
Download full validation report
