7QTQ
Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.
Functional Information from PROSITE/UniProt
| site_id | PS00484 |
| Number of Residues | 30 |
| Details | THYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. YvpqCaed.GsFqtvQcgkdgasc....WCVdad.G |
| Chain | Residue | Details |
| A | TYR48-GLY77 | |
| A | TYR116-GLY145 | |
| A | TYR315-GLY343 | |
| A | PHE615-GLY642 | |
| A | PHE682-GLY709 | |
| A | TYR1027-GLY1056 | |
| A | PHE1104-GLY1132 | |
| A | TYR1165-GLY1195 | |
| A | VAL1469-GLY1470 |
| site_id | PS00941 |
| Number of Residues | 11 |
| Details | CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVFvP |
| Chain | Residue | Details |
| A | GLU2279-PRO2289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Not glycosylated => ECO:0000269|PubMed:8424663 |
| Chain | Residue | Details |
| A | ASN198 | |
| B | ASN198 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Triiodothyronine; alternate => ECO:0000250|UniProtKB:P01266 |
| Chain | Residue | Details |
| A | TYR24 | |
| A | TYR703 | |
| A | T442573 | |
| A | TYR2766 | |
| B | TYR24 | |
| B | TYR703 | |
| B | T442573 | |
| B | TYR2766 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | MOD_RES: Iodotyrosine => ECO:0000250|UniProtKB:P01266 |
| Chain | Residue | Details |
| A | TYR108 | |
| B | TYR258 | |
| B | TYR784 | |
| B | TYR2184 | |
| B | TYR2587 | |
| B | TYR2617 | |
| A | TYR234 | |
| A | TYR258 | |
| A | TYR784 | |
| A | TYR2184 | |
| A | TYR2587 | |
| A | TYR2617 | |
| B | TYR108 | |
| B | TYR234 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: Iodotyrosine; alternate => ECO:0000250|UniProtKB:P01266 |
| Chain | Residue | Details |
| A | TYR149 | |
| A | TYR866 | |
| A | TYR992 | |
| A | TYR1467 | |
| B | TYR149 | |
| B | TYR866 | |
| B | TYR992 | |
| B | TYR1467 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Diiodotyrosine => ECO:0000250|UniProtKB:P01266 |
| Chain | Residue | Details |
| A | TYR883 | |
| A | TYR2697 | |
| B | TYR883 | |
| B | TYR2697 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Thyroxine => ECO:0000250|UniProtKB:P01266 |
| Chain | Residue | Details |
| A | TYR1310 | |
| A | DHA2540 | |
| B | TYR1310 | |
| B | DHA2540 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; alternate => ECO:0000269|PubMed:8424663 |
| Chain | Residue | Details |
| A | ASN110 | |
| B | ASN110 | |
| B | ASN483 | |
| B | ASN495 | |
| B | ASN853 | |
| B | ASN947 | |
| B | ASN1140 | |
| B | ASN1776 | |
| B | ASN1870 | |
| B | ASN2250 | |
| A | ASN483 | |
| A | ASN495 | |
| A | ASN853 | |
| A | ASN947 | |
| A | ASN1140 | |
| A | ASN1776 | |
| A | ASN1870 | |
| A | ASN2250 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:8424663 |
| Chain | Residue | Details |
| A | ASN1365 | |
| A | ASN2014 | |
| A | ASN2122 | |
| A | ASN2295 | |
| B | ASN1365 | |
| B | ASN2014 | |
| B | ASN2122 | |
| B | ASN2295 |
