5LGP

Crystal structure of mouse CARM1 in complex with ligand P1C3s

Summary for 5LGP

DescriptorHistone-arginine methyltransferase CARM1, Polyadenylate-binding protein 1, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordsprotein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
Biological sourceMus musculus (House Mouse)
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Cellular locationNucleus Q9WVG6
Cytoplasm P11940
Total number of polymer chains8
Total molecular weight170484.02
Authors
Marechal, N.,Troffer-Charlier, N.,Cura, V.,Bonnefond, L.,Cavarelli, J. (deposition date: 2016-07-08, release date: 2017-03-22, Last modification date: 2017-04-12)
Primary citation
van Haren, M.J.,Marechal, N.,Troffer-Charlier, N.,Cianciulli, A.,Sbardella, G.,Cavarelli, J.,Martin, N.I.
Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Proc. Natl. Acad. Sci. U.S.A., 114:3625-3630, 2017
PubMed: 28330993 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1618401114
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.04 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.219300.3%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution