5LGP
Crystal structure of mouse CARM1 in complex with ligand P1C3s
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | SER406 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | GLN174 |
| A | LEU178 |
| A | GLN205 |
| A | HOH606 |
| D | ASP458 |
| D | THR460 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 501 |
| Chain | Residue |
| C | PHE475 |
| C | TYR477 |
| H | PHE-7 |
| C | VAL341 |
| C | TYR417 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 501 |
| Chain | Residue |
| D | TRP404 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide QVR E 101 and ARG E 9 |
| Chain | Residue |
| A | TYR150 |
| A | PHE151 |
| A | PHE153 |
| A | TYR154 |
| A | MET163 |
| A | GLY193 |
| A | GLU215 |
| A | ALA216 |
| A | GLY241 |
| A | LYS242 |
| A | VAL243 |
| A | GLU244 |
| A | GLU258 |
| A | MET260 |
| A | GLU267 |
| A | MET269 |
| A | SER272 |
| A | HIS415 |
| A | TRP416 |
| A | HOH629 |
| A | HOH632 |
| A | HOH701 |
| E | ALA-1 |
| E | ILE0 |
| E | PRO2 |
| E | HOH202 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide ACE F 0 and PHE F 1 |
| Chain | Residue |
| A | PHE475 |
| B | HOH716 |
| E | ALA-1 |
| E | ALA3 |
| F | GLN-6 |
| F | ASN-5 |
| F | MET-4 |
| F | HOH201 |
| F | HOH202 |
| site_id | AC8 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide QVR F 101 and ARG F 9 |
| Chain | Residue |
| B | TYR150 |
| B | PHE151 |
| B | PHE153 |
| B | TYR154 |
| B | GLN159 |
| B | MET163 |
| B | GLY193 |
| B | GLU215 |
| B | ALA216 |
| B | GLY241 |
| B | LYS242 |
| B | VAL243 |
| B | GLU244 |
| B | GLU258 |
| B | MET260 |
| B | GLU267 |
| B | MET269 |
| B | SER272 |
| B | HIS415 |
| B | HOH644 |
| B | HOH656 |
| B | HOH659 |
| F | ALA-1 |
| F | ILE0 |
| F | PRO2 |
| site_id | AD1 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide QVR G 101 and ARG G 9 |
| Chain | Residue |
| C | PHE138 |
| C | TYR150 |
| C | PHE151 |
| C | PHE153 |
| C | TYR154 |
| C | MET163 |
| C | GLY193 |
| C | GLU215 |
| C | ALA216 |
| C | LYS242 |
| C | VAL243 |
| C | GLU244 |
| C | GLU258 |
| C | MET260 |
| C | GLU267 |
| C | MET269 |
| C | SER272 |
| C | HIS415 |
| C | TRP416 |
| C | HOH633 |
| C | HOH665 |
| G | ALA-1 |
| G | ILE0 |
| G | PRO2 |
| G | HOH201 |
| G | HOH203 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE H 0 and PHE H 1 |
| Chain | Residue |
| C | EDO501 |
| D | HOH698 |
| G | ALA-1 |
| G | ALA3 |
| H | GLN-6 |
| H | ASN-5 |
| H | MET-4 |
| H | HOH201 |
| site_id | AD4 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide QVR H 101 and ARG H 9 |
| Chain | Residue |
| D | PHE138 |
| D | TYR150 |
| D | PHE151 |
| D | PHE153 |
| D | TYR154 |
| D | MET163 |
| D | GLY193 |
| D | GLU215 |
| D | ALA216 |
| D | GLY241 |
| D | LYS242 |
| D | VAL243 |
| D | GLU244 |
| D | GLU258 |
| D | MET260 |
| D | GLU267 |
| D | MET269 |
| D | SER272 |
| D | HIS415 |
| D | HOH632 |
| D | HOH684 |
| D | HOH693 |
| H | ALA-1 |
| H | ILE0 |
| H | PRO2 |
| H | ALA3 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1228 |
| Details | Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 132 |
| Details | Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Omega-N-methylated arginine; by CARM1; partial","evidences":[{"source":"PubMed","id":"11850402","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
