3O0G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3o0g by Molmil](/molmil-images/mine/3o0g) | Crystal Structure of Cdk5:p25 in complex with an ATP analogue | Descriptor: | Cell division protein kinase 5, Cyclin-dependent kinase 5 activator 1, {4-amino-2-[(4-chlorophenyl)amino]-1,3-thiazol-5-yl}(3-nitrophenyl)methanone | Authors: | Mapelli, M. | Deposit date: | 2010-07-19 | Release date: | 2011-01-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Defining Cdk5 ligand chemical space with small molecule inhibitors of Tau phosphorylation Chem.Biol., 12, 2005
|
|
2V64
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2v64 by Molmil](/molmil-images/mine/2v64) | Crystallographic structure of the conformational dimer of the Spindle Assembly Checkpoint protein Mad2. | Descriptor: | MBP1, MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A | Authors: | Mapelli, M, Massimiliano, L, Santaguida, S, Musacchio, A. | Deposit date: | 2007-07-13 | Release date: | 2007-11-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The MAD2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint Cell(Cambridge,Mass.), 131, 2007
|
|
5NJJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5njj by Molmil](/molmil-images/mine/5njj) | PTB domain of human Numb isoform-1 | Descriptor: | ALA-TYR-ILE-GLY-PRO-PTR-LEU, Protein numb homolog, SULFATE ION | Authors: | Mapelli, M, Di Fiore, P.P. | Deposit date: | 2017-03-29 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer. J. Cell Biol., 217, 2018
|
|
5NJK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5njk by Molmil](/molmil-images/mine/5njk) | PTB domain of human Numb isoform-1 | Descriptor: | ALA-TYR-ILE-GLY-PRO-PTR-LEU, Protein numb homolog, SULFATE ION | Authors: | Mapelli, M, Di Fiore, P.P. | Deposit date: | 2017-03-29 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer. J. Cell Biol., 217, 2018
|
|
1UNL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1unl by Molmil](/molmil-images/mine/1unl) | Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin. | Descriptor: | CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, R-ROSCOVITINE | Authors: | Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A. | Deposit date: | 2003-09-10 | Release date: | 2004-11-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of Cdk5/P25 Binding by Cdk Inhibitors J.Med.Chem., 48, 2005
|
|
1UNG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ung by Molmil](/molmil-images/mine/1ung) | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | Descriptor: | 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE, CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 | Authors: | Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A. | Deposit date: | 2003-09-10 | Release date: | 2004-11-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanism of Cdk5/P25 Binding by Cdk Inhibitors J.Med.Chem., 48, 2005
|
|
1UNH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1unh by Molmil](/molmil-images/mine/1unh) | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | Descriptor: | (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME, CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 | Authors: | Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A. | Deposit date: | 2003-09-10 | Release date: | 2004-11-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Mechanism of Cdk5/P25 Binding by Cdk Inhibitors J.Med.Chem., 48, 2005
|
|
6QJA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qja by Molmil](/molmil-images/mine/6qja) | Organizational principles of the NuMA-Dynein interaction interface and implications for mitotic spindle functions | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Nuclear mitotic apparatus protein 1 | Authors: | Renna, C, Rizzelli, F, Carminati, M, Gaddoni, C, Pirovano, L, Cecatiello, V, Pasqualato, S, Mapelli, M. | Deposit date: | 2019-01-23 | Release date: | 2020-02-05 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions. Structure, 28, 2020
|
|
6HC2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hc2 by Molmil](/molmil-images/mine/6hc2) | Crystal structure of NuMA/LGN hetero-hexamers | Descriptor: | G-protein-signaling modulator 2, Nuclear mitotic apparatus protein 1 | Authors: | Pasqualato, S, Culurgioni, S, Foadi, J, Alfieri, A, Mapelli, M. | Deposit date: | 2018-08-13 | Release date: | 2019-05-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (4.31 Å) | Cite: | Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions. Nat Commun, 10, 2019
|
|
5A7D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a7d by Molmil](/molmil-images/mine/5a7d) | Tetrameric assembly of LGN with Inscuteable | Descriptor: | INSCUTEABLE, PINS | Authors: | Culurgioni, S, Mari, S, Bonetto, G, Gallini, S, Brennich, M, Round, A, Mapelli, M. | Deposit date: | 2015-07-07 | Release date: | 2016-08-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | The Structure of the Insc:Lgn Tetramer Reveals a New Function of Lgn in Promoting Asymmetric Cell Divisions To be Published
|
|
5A6C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a6c by Molmil](/molmil-images/mine/5a6c) | Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation | Descriptor: | G-PROTEIN-SIGNALING MODULATOR 2, AFADIN, SULFATE ION | Authors: | Carminati, M, Gallini, S, Pirovano, L, Alfieri, A, Bisi, S, Mapelli, M. | Deposit date: | 2015-06-25 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.901 Å) | Cite: | Concomitant Binding of Afadin to Lgn and F-Actin Directs Planar Spindle Orientation. Nat.Struct.Mol.Biol., 23, 2016
|
|
4A7J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4a7j by Molmil](/molmil-images/mine/4a7j) | Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance | Descriptor: | HISTONE H3.1T, WD REPEAT-CONTAINING PROTEIN 5 | Authors: | Migliori, V, Muller, J, Phalke, S, Low, D, Bezzi, M, ChuenMok, W, Gunaratne, J, Capasso, P, Bassi, C, Cecatiello, V, DeMarco, A, Blackstock, W, Kuznetsov, V, Amati, B, Mapelli, M, Guccione, E. | Deposit date: | 2011-11-14 | Release date: | 2012-01-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Symmetric Dimethylation of H3R2 is a Newly Identified Histone Mark that Supports Euchromatin Maintenance Nat.Struct.Mol.Biol., 19, 2012
|
|
4A1S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4a1s by Molmil](/molmil-images/mine/4a1s) | Crystallographic structure of the Pins:Insc complex | Descriptor: | PARTNER OF INSCUTEABLE, RE60102P | Authors: | Culurgioni, S, Alfieri, A, Pendolino, V, Laddomada, F, Mapelli, M. | Deposit date: | 2011-09-19 | Release date: | 2012-03-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Inscuteable and Numa Proteins Bind Competitively to Leu-Gly- Asn Repeat-Enriched Protein (Lgn) During Asymmetric Cell Divisions. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
6ZT0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zt0 by Molmil](/molmil-images/mine/6zt0) | Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex | Descriptor: | 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald | Authors: | Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M. | Deposit date: | 2020-07-17 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions. Nat Commun, 12, 2021
|
|
6ZSZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zsz by Molmil](/molmil-images/mine/6zsz) | |
6ZSY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zsy by Molmil](/molmil-images/mine/6zsy) | |
1GO4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1go4 by Molmil](/molmil-images/mine/1go4) | Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20. | Descriptor: | Mitotic spindle assembly checkpoint protein MAD1, Mitotic spindle assembly checkpoint protein MAD2A | Authors: | Sironi, L, Mapelli, M, Jeang, K.T, Musacchio, A. | Deposit date: | 2001-10-17 | Release date: | 2002-05-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J., 21, 2002
|
|
1URJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1urj by Molmil](/molmil-images/mine/1urj) | Single stranded DNA-binding protein(ICP8) from Herpes simplex virus-1 | Descriptor: | MAJOR DNA-BINDING PROTEIN, MERCURY (II) ION, ZINC ION | Authors: | Panjikar, S, Mapelli, M, Tucker, P.A. | Deposit date: | 2003-10-30 | Release date: | 2004-11-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding. J. Biol. Chem., 280, 2005
|
|
2C7N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2c7n by Molmil](/molmil-images/mine/2c7n) | Human Rabex-5 residues 1-74 in complex with Ubiquitin | Descriptor: | RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, UBIQUITIN, ZINC ION | Authors: | Penengo, L, Mapelli, M, Murachelli, A.G, Confalioneri, S, Magri, L, Musacchio, A, Di Fiore, P.P, Polo, S, Schneider, T.R. | Deposit date: | 2005-11-25 | Release date: | 2006-02-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with Ubiquitin. Cell(Cambridge,Mass.), 124, 2006
|
|
2C7M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2c7m by Molmil](/molmil-images/mine/2c7m) | Human Rabex-5 residues 1-74 in complex with Ubiquitin | Descriptor: | RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, UBIQUITIN, ZINC ION | Authors: | Penengo, L, Mapelli, M, Murachelli, A.G, Confalioneri, S, Magri, L, Musacchio, A, Di Fiore, P.P, Polo, S, Schneider, T.R. | Deposit date: | 2005-11-25 | Release date: | 2006-02-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell, 124, 2006
|
|
2BFY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bfy by Molmil](/molmil-images/mine/2bfy) | Complex of Aurora-B with INCENP and Hesperadin. | Descriptor: | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE | Authors: | Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A. | Deposit date: | 2004-12-15 | Release date: | 2005-05-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin Mol.Cell, 18, 2005
|
|
2BFX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bfx by Molmil](/molmil-images/mine/2bfx) | Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin. | Descriptor: | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A | Authors: | Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A. | Deposit date: | 2004-12-15 | Release date: | 2005-05-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin Mol.Cell, 18, 2005
|
|