7OQM
 
 | | Human OMPD-domain of UMPS in complex with substrate OMP at 1.05 Angstroms resolution, 20 minutes soaking | | 分子名称: | GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... | | 著者 | Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K. | | 登録日 | 2021-06-03 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
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7OQN
 | | Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 30 minutes soaking | | 分子名称: | GLYCEROL, SULFATE ION, URIDINE-5'-MONOPHOSPHATE, ... | | 著者 | Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K. | | 登録日 | 2021-06-03 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
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7OQF
 | | Human OMPD-domain of UMPS in complex with OMP at 1.05 Angstrom resolution, 5 minutes soaking | | 分子名称: | GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... | | 著者 | Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K. | | 登録日 | 2021-06-03 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
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7OQI
 | | Human OMPD-domain of UMPS in complex with substrate OMP at 1.15 Angstrom resolution, 10 minutes soaking | | 分子名称: | GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... | | 著者 | Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K. | | 登録日 | 2021-06-03 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
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7OQK
 | | Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 15 minutes soaking | | 分子名称: | GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... | | 著者 | Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K. | | 登録日 | 2021-06-03 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
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7A9W
 | | Structure of yeast Rmd9p in complex with 20nt target RNA | | 分子名称: | CHLORIDE ION, Protein RMD9, mitochondrial, ... | | 著者 | Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M. | | 登録日 | 2020-09-02 | | 公開日 | 2021-04-07 | | 最終更新日 | 2021-05-05 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7A9X
 | | Structure of yeast Rmd9p in complex with 16nt target RNA | | 分子名称: | CHLORIDE ION, Protein RMD9, mitochondrial, ... | | 著者 | Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M. | | 登録日 | 2020-09-02 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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2WRS
 | | Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa | | 分子名称: | BETA-LACTAMASE VIM-4, CITRATE ANION, CITRIC ACID, ... | | 著者 | Lassaux, P, Hamel, M, Gulea, M, Delbruck, H, Traore, D.A.K, Mercuri, P.S, Horsfall, L, Dehareng, D, Gaumont, A.-C, Frere, J.-M, Ferrer, J.-L, Hoffmann, K, Galleni, M, Bebrone, C. | | 登録日 | 2009-09-02 | | 公開日 | 2010-06-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-Beta-Lactamases.
J.Med.Chem., 53, 2010
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6YJY
 | | Crystal structure of human glutaminyl cyclase in complex with neurotensin 1-5 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTAMINE, Glutaminyl-peptide cyclotransferase, ... | | 著者 | Funk, L.M, Sautner, V, Tittmann, K. | | 登録日 | 2020-04-05 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.
Biochemistry, 59, 2020
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3OC4
 | | Crystal Structure of a pyridine nucleotide-disulfide family oxidoreductase from the Enterococcus faecalis V583 | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Oxidoreductase, pyridine nucleotide-disulfide family, ... | | 著者 | Kumaran, D, Baumann, K, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2010-08-09 | | 公開日 | 2010-10-06 | | 最終更新日 | 2021-02-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal Structure of a pyridine nucleotide-disulfide family oxidoreductase from the Enterococcus faecalis V583
To be Published
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2WX0
 | | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | | 著者 | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | | 登録日 | 2009-10-30 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
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6QL5
 | | Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 2.8 angstrom | | 分子名称: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | 登録日 | 2019-01-31 | | 公開日 | 2020-03-18 | | 最終更新日 | 2020-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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8ADB
 | | Viral tegument-like DUBs | | 分子名称: | CITRIC ACID, Polyubiquitin-C, Wc-VDT1, ... | | 著者 | Erven, I, Abraham, E.T, Hermanns, T, Baumann, U, Hofmann, K. | | 登録日 | 2022-07-08 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.
Nat Commun, 13, 2022
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8ADC
 | | Viral tegument-like DUBs | | 分子名称: | Viral deubiquitinating enzyme | | 著者 | Erven, I, Abraham, E.T, Hermanns, T, Baumann, U, Hofmann, K. | | 登録日 | 2022-07-08 | | 公開日 | 2023-02-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.
Nat Commun, 13, 2022
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1H4B
 | | SOLUTION STRUCTURE OF THE BIRCH POLLEN ALLERGEN BET V 4 | | 分子名称: | CALCIUM ION, POLCALCIN BET V 4 | | 著者 | Neudecker, P, Nerkamp, J, Eisenmann, A, Lauber, T, Lehmann, K, Schweimer, K, Roesch, P. | | 登録日 | 2003-02-26 | | 公開日 | 2004-02-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure, Dynamics, and Hydrodynamics of the Calcium-Bound Cross-Reactive Birch Pollen Allergen Bet V 4 Reveal a Canonical Monomeric Two EF-Hand Assembly with a Regulatory Function
J.Mol.Biol., 336, 2004
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6QL7
 | | Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom | | 分子名称: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17 | | 著者 | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | 登録日 | 2019-01-31 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (4.6 Å) | | 主引用文献 | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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6QL6
 | | Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... | | 著者 | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | 登録日 | 2019-01-31 | | 公開日 | 2020-03-18 | | 最終更新日 | 2020-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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6QL9
 | | Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | | 分子名称: | 1,2-ETHANEDIOL, 4'-PHOSPHOPANTETHEINE, ACETATE ION, ... | | 著者 | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | 登録日 | 2019-01-31 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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5ICP
 | | CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone | | 分子名称: | 1,2-ETHANEDIOL, Cyclin-C, Cyclin-dependent kinase 8, ... | | 著者 | Musil, D, Blagg, J, Mallinger, A, Czodrowski, P, Schiemann, K. | | 登録日 | 2016-02-23 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
J. Med. Chem., 59, 2016
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5IDN
 | | CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone | | 分子名称: | 1,2-ETHANEDIOL, Cyclin-C, Cyclin-dependent kinase 8, ... | | 著者 | Musil, D, Blagg, J, Mallinger, A, Czodrowski, P, Schiemann, K. | | 登録日 | 2016-02-24 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
J. Med. Chem., 59, 2016
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6HAF
 | | Pyruvate oxidase variant E59Q from L. plantarum in complex with phosphate | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Funk, L.M, Sautner, V, Tittmann, K. | | 登録日 | 2018-08-07 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Low-barrier hydrogen bonds in enzyme cooperativity.
Nature, 573, 2019
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3PQR
 | | Crystal structure of Metarhodopsin II in complex with a C-terminal peptide derived from the Galpha subunit of transducin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, ... | | 著者 | Choe, H.-W, Kim, Y.J, Park, J.H, Morizumi, T, Pai, E.F, Krauss, N, Hofmann, K.P, Scheerer, P, Ernst, O.P. | | 登録日 | 2010-11-26 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Crystal structure of metarhodopsin II.
Nature, 471, 2011
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6HIJ
 | | Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked | | 分子名称: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ATP-binding cassette sub-family G member 2, CHOLESTEROL, ... | | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | | 登録日 | 2018-08-30 | | 公開日 | 2018-09-19 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat.Struct.Mol.Biol., 25, 2018
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2KIE
 | | A PH domain within OCRL bridges clathrin mediated membrane trafficking to phosphoinositide metabolis | | 分子名称: | Inositol polyphosphate 5-phosphatase OCRL-1 | | 著者 | Mao, Y, Balkin, D.M, Zoncu, R, Erdmann, K, Tomasini, L, Hu, F, Jin, M.M, Hodsdon, M.E, De Camilli, P. | | 登録日 | 2009-05-03 | | 公開日 | 2009-07-21 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
Embo J., 28, 2009
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1Q7X
 | | Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E) | | 分子名称: | PDZ2b domain of PTP-Bas (hPTP1E) | | 著者 | Kachel, N, Erdmann, K.S, Kremer, W, Wolff, P, Gronwald, W, Heumann, R, Kalbitzer, H.R, Structural Proteomics in Europe (SPINE) | | 登録日 | 2003-08-20 | | 公開日 | 2003-12-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): Splicing induced modulation of ligand specificity.
J.Mol.Biol., 334, 2003
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