6YJY

Crystal structure of human glutaminyl cyclase in complex with neurotensin 1-5

Summary for 6YJY

• Entry DOI: 10.2210/pdb6yjy/pdb
• Related: 6YI1
• Descriptor: Glutaminyl-peptide cyclotransferase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (9 entities in total)
• Functional Keywords: alpha-beta protein, metalloprotein, transferase, intermediate
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 78407.40

Authors

Funk, L.M.,Sautner, V.,Tittmann, K. (deposition date: 2020-04-05, release date: 2020-07-01, Last modification date: 2024-01-24)

• Primary citation: Kupski, O.,Funk, L.M.,Sautner, V.,Seifert, F.,Worbs, B.,Ramsbeck, D.,Meyer, F.,Diederichsen, U.,Buchholz, M.,Schilling, S.,Demuth, H.U.,Tittmann, K.; Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.; Biochemistry, 59:2585-2591, 2020; PubMed: 32551535; DOI: 10.1021/acs.biochem.0c00337

Experimental method

X-RAY DIFFRACTION (1.67 Å)