6YJY
Crystal structure of human glutaminyl cyclase in complex with neurotensin 1-5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Glutaminyl-peptide cyclotransferase | polymer | 329 | 37553.4 | 2 | UniProt (Q16769) Pfam (PF04389) In PDB | Homo sapiens (Human) | Glutaminyl cyclase,sQC,Glutaminyl-tRNA cyclotransferase,Glutamyl cyclase,EC |
| 2 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 17 | Chemie (SO4) | |||
| 4 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | B, A | PYROGLUTAMIC ACID | non-polymer | 129.1 | 2 | Chemie (PCA) | |||
| 6 | B, A | LEUCINE | non-polymer | 131.2 | 3 | Chemie (LEU) | |||
| 7 | B, A | TYROSINE | non-polymer | 181.2 | 3 | Chemie (TYR) | |||
| 8 | B | GLUTAMINE | non-polymer | 146.1 | 1 | Chemie (GLN) | |||
| 9 | water | water | 18.0 | 481 | Chemie (HOH) |
Sequence modifications
A, B: 35 - 361 (UniProt: Q16769)
| PDB | External Database | Details |
|---|---|---|
| Gly 33 | - | expression tag |
| Pro 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75106.8 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 3300.6 | |
| All* | Total formula weight | 78407.4 |
