6YI1

Crystal structure of human glutaminyl cyclase in complex with Glu(gamma-hydrazide)-Phe-Ala

Summary for 6YI1

• Entry DOI: 10.2210/pdb6yi1/pdb
• Descriptor: Glutaminyl-peptide cyclotransferase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glu(gamma-hydrazide)-Phe-Ala, ... (11 entities in total)
• Functional Keywords: alpha-beta protein, metalloprotein, transferase, intermediate
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 80254.53

Authors

Kupski, O.,Sautner, V.,Tittmann, K. (deposition date: 2020-03-31, release date: 2020-07-01, Last modification date: 2024-02-07)

• Primary citation: Kupski, O.,Funk, L.M.,Sautner, V.,Seifert, F.,Worbs, B.,Ramsbeck, D.,Meyer, F.,Diederichsen, U.,Buchholz, M.,Schilling, S.,Demuth, H.U.,Tittmann, K.; Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.; Biochemistry, 59:2585-2591, 2020; PubMed: 32551535; DOI: 10.1021/acs.biochem.0c00337

Experimental method

X-RAY DIFFRACTION (1.92 Å)