6YI1
Crystal structure of human glutaminyl cyclase in complex with Glu(gamma-hydrazide)-Phe-Ala
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutaminyl-peptide cyclotransferase | polymer | 329 | 37553.4 | 2 | UniProt (Q16769) Pfam (PF04389) | Homo sapiens (human) | Glutaminyl cyclase,sQC,Glutaminyl-tRNA cyclotransferase,Glutamyl cyclase,EC |
| 2 | C, D, E (C, D, E) | Glu(gamma-hydrazide)-Phe-Ala | polymer | 4 | 377.4 | 3 | Synthetic construct | ||
| 3 | DA, EA, F, FA, GA... (B, A) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 4 | AA, BA, CA, G, H... (B, A) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 5 | HA, IA, JA, O, P (B, A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | Q (A) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 1 | Chemie (DIO) | |||
| 7 | R, S, T (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) | |||
| 8 | MA, NA, U, V, W (B, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) | |||
| 9 | KA, LA (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 10 | PA, QA (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 11 | SA, TA (A, B) | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A, B: 35 - 361 (UniProt: Q16769)
| PDB | External Database | Details |
|---|---|---|
| Gly 33 | - | expression tag |
| Pro 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 76239.1 | |
| Non-Polymers* | Number of molecules | 39 |
| Total formula weight | 4063.5 | |
| All* | Total formula weight | 80302.5 |
