2PLU
| Crystal structure of Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 | Descriptor: | 20k cyclophilin, putative | Authors: | Wernimont, A.K, Lew, J, Hills, T, Kozieradzki, I, Lin, Y.H, Hassanali, A, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Artz, J.D, Xiao, T, Structural Genomics Consortium (SGC) | Deposit date: | 2007-04-20 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structure of Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120. To be Published
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5FGA
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5LW7
| S. solfataricus ABCE1 post-splitting state | Descriptor: | ABC transporter ATP-binding protein, IRON/SULFUR CLUSTER | Authors: | Heuer, A, Gerovac, M, Beckmann, R, Tampe, R. | Deposit date: | 2016-09-15 | Release date: | 2016-11-16 | Last modified: | 2019-02-20 | Method: | ELECTRON MICROSCOPY (17 Å) | Cite: | Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry. Nat Commun, 7, 2016
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6I5W
| BlMnBP1 binding protein of an ABC transporter from Bifidobacterium animalis subsp. lactis ATCC27673 in complex with mannobiose | Descriptor: | ACETATE ION, Solute Binding Protein BlMnBP1, Blac_00780 in complex with mannopentaose, ... | Authors: | Abou Hachem, M, Ejby, M, Guskov, A, Slotboom, D.J. | Deposit date: | 2018-11-14 | Release date: | 2019-04-17 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on beta-mannan possess distinct manno-oligosaccharide-binding profiles. Mol.Microbiol., 112, 2019
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5LTS
| Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease Mutant D118A | Descriptor: | CHLORIDE ION, GLYCEROL, RNA-directed RNA polymerase L, ... | Authors: | Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. | Deposit date: | 2016-09-07 | Release date: | 2017-09-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. IUCrJ, 5, 2018
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2UZS
| A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K) | Descriptor: | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-alpha serine/threonine-protein kinase | Authors: | Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E. | Deposit date: | 2007-05-01 | Release date: | 2007-07-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature, 448, 2007
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8HG7
| Structure of human SGLT2-MAP17 complex with Sotagliflozin | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-11-14 | Release date: | 2023-11-15 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HEZ
| Structure of human SGLT2-MAP17 complex with Dapagliflozin | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-11-09 | Release date: | 2023-11-15 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HDH
| Structure of human SGLT2-MAP17 complex with Canagliflozin | Descriptor: | (2~{S},3~{R},4~{R},5~{S},6~{R})-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methyl-phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-11-04 | Release date: | 2023-11-08 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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2V1M
| Crystal structure of Schistosoma mansoni glutathione peroxidase | Descriptor: | ACETATE ION, GLUTATHIONE PEROXIDASE, LITHIUM ION, ... | Authors: | Dimastrogiovanni, D, Miele, A.E, Angelucci, F, Boumis, G, Bellelli, A, Brunori, M. | Deposit date: | 2008-09-16 | Release date: | 2009-09-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Combining Crystallography and Molecular Dynamics: The Case of Schistosoma Mansoni Phospholipid Glutathione Peroxidase. Proteins, 78, 2010
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5J5S
| Src kinase in complex with a sulfonamide inhibitor | Descriptor: | N-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src | Authors: | Lebedev, I, Feldman, H.C, Georghiou, G, Maly, D.J, Seeliger, M. | Deposit date: | 2016-04-03 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.153 Å) | Cite: | Structural and Functional Analysis of the Allosteric Modulation of IRE1a with ATP-Competitive Kinase Inhibitors To Be Published
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1GC0
| CRYSTAL STRUCTURE OF THE PYRIDOXAL-5'-PHOSPHATE DEPENDENT L-METHIONINE GAMMA-LYASE FROM PSEUDOMONAS PUTIDA | Descriptor: | METHIONINE GAMMA-LYASE | Authors: | Motoshima, H, Inagaki, K, Kumasaka, T, Furuichi, M, Inoue, H, Tamura, T, Esaki, N, Soda, K, Tanaka, N, Yamamoto, M, Tanaka, H. | Deposit date: | 2000-07-06 | Release date: | 2002-05-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putida. J.Biochem., 128, 2000
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1GDQ
| FUSARIUM OXYSPORUM TRYPSIN AT ATOMIC RESOLUTION | Descriptor: | GLY-ALA-ARG, GLYCEROL, SULFATE ION, ... | Authors: | Rypniewski, W.R, Oestergaard, P, Noerregaard-Madsen, M, Dauter, M, Wilson, K.S. | Deposit date: | 2000-09-28 | Release date: | 2001-02-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (0.93 Å) | Cite: | Fusarium oxysporum trypsin at atomic resolution at 100 and 283 K: a study of ligand binding. Acta Crystallogr.,Sect.D, 57, 2001
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8HIN
| Structure of human SGLT2-MAP17 complex with Phlorizin | Descriptor: | 1-[2-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,6-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | Deposit date: | 2022-11-21 | Release date: | 2023-11-22 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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2B13
| Truncated S. aureus LytM, P41 crystal form | Descriptor: | Glycyl-glycine endopeptidase lytM, L(+)-TARTARIC ACID, ZINC ION | Authors: | Firczuk, M, Mucha, A, Bochtler, M. | Deposit date: | 2005-09-15 | Release date: | 2006-01-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structures of active LytM. J.Mol.Biol., 354, 2005
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7BJZ
| GLUCOSE ISOMERASE S171W in H32 | Descriptor: | MANGANESE (II) ION, Xylose isomerase | Authors: | Sleutel, M. | Deposit date: | 2021-01-14 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Nucleation of protein mesocrystals via oriented attachment. Nat Commun, 12, 2021
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2VBT
| Riboflavin kinase Mj0056 from Methanocaldococcus jannaschii in complex with CDP and PO4 | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, PHOSPHATE ION, RIBOFLAVIN KINASE, ... | Authors: | Hartmann, M.D, Ammelburg, M, Djuranovic, S, Martin, J, Lupas, A.N, Zeth, K. | Deposit date: | 2007-09-16 | Release date: | 2007-11-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A Ctp-Dependent Archaeal Riboflavin Kinase Forms a Bridge in the Evolution of Cradle-Loop Barrels. Structure, 15, 2007
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2B34
| Structure of MAR1 Ribonuclease from Caenorhabditis elegans | Descriptor: | MAR1 Ribonuclease | Authors: | Schormann, N, Karpova, E, Li, S, Symersky, J, Zhang, Y, Lu, S, Zhou, Q, Lin, G, Cao, Z, Luo, M, Qiu, S, Luan, C.-H, Luo, D, Huang, W, Shang, Q, McKinstry, A, An, J, Tsao, J, Carson, M, Stinnett, M, Chen, Y, Johnson, D, Gary, R, Arabshahi, A, Bunzel, R, Bray, T, DeLucas, L, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2005-09-19 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.141 Å) | Cite: | Structure of MAR1 Ribonuclease from Caenorhabditis elegans To be Published
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6FU1
| Crystal structure of Schistosoma mansoni HDAC8 complexed with a n-alkyl hydroxamate | Descriptor: | GLYCEROL, Histone deacetylase, POTASSIUM ION, ... | Authors: | Marek, M, Shaik, T.B, Romier, C. | Deposit date: | 2018-02-26 | Release date: | 2019-03-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.548 Å) | Cite: | A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing. Molecules, 23, 2018
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2VFX
| Structure of the Symmetric Mad2 Dimer | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, ... | Authors: | Yang, M, Li, B, Liu, C.-J, Tomchick, D.R, Machius, M, Rizo, J, Yu, H, Luo, X. | Deposit date: | 2007-11-05 | Release date: | 2008-03-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer. Plos Biol., 6, 2008
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5FG7
| Yeast 20S proteasome beta2-T1A mutant | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | Authors: | Huber, E.M, Groll, M. | Deposit date: | 2015-12-20 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome. Nat Commun, 7, 2016
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2BAX
| Atomic Resolution Structure of the Double Mutant (K53,56M) of Bovine Pancreatic Phospholipase A2 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ... | Authors: | Sekar, K, Yogavel, M, Velmurugan, D, Dauter, Z, Dauter, M, Tsai, M.D. | Deposit date: | 2005-10-15 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2. Acta Crystallogr.,Sect.F, 61, 2005
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5MDU
| Structure of the RNA recognition motif (RRM) of Seb1 from S. pombe. | Descriptor: | CHLORIDE ION, GLYCEROL, Rpb7-binding protein seb1, ... | Authors: | Wittmann, S, Renner, M, El Omari, K, Adams, O, Vasiljeva, L, Grimes, J. | Deposit date: | 2016-11-13 | Release date: | 2017-04-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Nat Commun, 8, 2017
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8HOK
| crystal structure of UGT71AP2 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, UGT71AP2 | Authors: | Wang, Z.L, He, C, Li, F, Qiao, X, Ye, M. | Deposit date: | 2022-12-10 | Release date: | 2023-12-13 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Functional characterization, structural basis, and protein engineering of a rare flavonoid 2'-O-glycosyltransferase from Scutellaria baicalensis. Acta Pharm Sin B, 2024
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3KW6
| Crystal Structure of a domain of 26S proteasome regulatory subunit 8 from homo sapiens. Northeast Structural Genomics Consortium target id HR3102A | Descriptor: | 26S protease regulatory subunit 8 | Authors: | Seetharaman, J, Su, M, Wang, D, Janjua, H, Cunningham, K, Owens, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-11-30 | Release date: | 2009-12-22 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of a domain of 26S proteasome regulatory subunit 8 from homo sapiens. Northeast Structural Genomics Consortium target id HR3102A To be Published
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