5H0G
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![BU of 5h0g by Molmil](/molmil-images/mine/5h0g) | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,4-dimethylpentanamide | Descriptor: | (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},4-dimethyl-pentanamide, Tyrosine-protein kinase HCK | Authors: | Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. | Deposit date: | 2016-10-04 | Release date: | 2017-10-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
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6QE2
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![BU of 6qe2 by Molmil](/molmil-images/mine/6qe2) | Crystal structure of Paleococcus ferrophilus monoacylglycerol lipase. | Descriptor: | GLYCEROL, LAURYL DIMETHYLAMINE-N-OXIDE, Monoacylglycerol lipase | Authors: | Labar, G, Demarez, M, Brandt, N, Wouters, J, Leherte, F. | Deposit date: | 2019-01-04 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7461 Å) | Cite: | Structure and Dynamics of an Archeal Monoglyceride Lipase from Palaeococcus ferrophilus as Revealed by Crystallography and In Silico Analysis. Biomolecules, 11, 2021
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1ZYI
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![BU of 1zyi by Molmil](/molmil-images/mine/1zyi) | Solution structure of ICLN, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing | Descriptor: | Methylosome subunit pICln | Authors: | Fuerst, J, Schedlbauer, A, Gandini, R, Garavaglia, M.L, Siano, S, Gschwentner, M, Sarg, B, Kontaxis, G, Konrat, R, Paulmichl, M. | Deposit date: | 2005-06-10 | Release date: | 2005-06-28 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4 J.Biol.Chem., 280, 2005
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6Q04
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![BU of 6q04 by Molmil](/molmil-images/mine/6q04) | MERS-CoV S structure in complex with 5-N-acetyl neuraminic acid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ... | Authors: | Park, Y.J, Walls, A.C, Wang, Z, Sauer, M, Li, W, Tortorici, M.A, Bosch, B.J, DiMaio, F.D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2019-08-01 | Release date: | 2019-12-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. Nat.Struct.Mol.Biol., 26, 2019
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5NBS
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![BU of 5nbs by Molmil](/molmil-images/mine/5nbs) | Structural studies of a Glycoside Hydrolase Family 3 beta-glucosidase from the Model Fungus Neurospora crassa | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-glucosidase, ... | Authors: | Gudmundsson, M, Karkehabadi, S, Kaper, T, Sandgren, M. | Deposit date: | 2017-03-02 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural studies of a glycoside hydrolase family 3 beta-glucosidase from the model fungus Neurospora crassa. Acta Crystallogr F Struct Biol Commun, 74, 2018
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1X41
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![BU of 1x41 by Molmil](/molmil-images/mine/1x41) | Solution structure of the Myb-like DNA binding domain of human Transcriptional adaptor 2-like, isoform B | Descriptor: | Transcriptional adaptor 2-like, isoform b | Authors: | Sasagawa, A, Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-12 | Release date: | 2005-11-12 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Myb-like DNA binding domain of human Transcriptional adaptor 2-like, isoform B To be Published
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6CU7
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![BU of 6cu7 by Molmil](/molmil-images/mine/6cu7) | Alpha Synuclein fibril formed by full length protein - Rod Polymorph | Descriptor: | Alpha-synuclein | Authors: | Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L. | Deposit date: | 2018-03-23 | Release date: | 2018-09-12 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun, 9, 2018
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7QDT
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![BU of 7qdt by Molmil](/molmil-images/mine/7qdt) | Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain designed to model dominant negative human mutations. | Descriptor: | 3,5,3'TRIIODOTHYRONINE, Isoform Alpha-1 of Thyroid hormone receptor alpha | Authors: | Romartinez-Alonso, B, Fairall, L, Agostini, M, Chatterjee, K, Schwabe, J. | Deposit date: | 2021-11-30 | Release date: | 2022-01-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone alpha. Mol.Cell.Biol., 42, 2022
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5KQO
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![BU of 5kqo by Molmil](/molmil-images/mine/5kqo) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Vibrio vulnificus | Descriptor: | 1,2-ETHANEDIOL, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, PHOSPHATE ION | Authors: | Ussin, N, Offermann, L.R, Perdue, M, Chruszcz, M. | Deposit date: | 2016-07-06 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural characterization of 1-deoxy-D-xylulose 5-phosphate Reductoisomerase from Vibrio vulnificus. Biochim Biophys Acta Proteins Proteom, 1866, 2018
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6HFO
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![BU of 6hfo by Molmil](/molmil-images/mine/6hfo) | Human Hsp90 co-chaperone TTC4 C-domain | Descriptor: | PHOSPHATE ION, Tetratricopeptide repeat protein 4 | Authors: | Huber, E.M, Groll, M. | Deposit date: | 2018-08-21 | Release date: | 2019-03-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2. Mol.Cell, 74, 2019
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5YJE
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![BU of 5yje by Molmil](/molmil-images/mine/5yje) | Crystal structure of HIRA(644-1017) | Descriptor: | Protein HIRA, SULFATE ION | Authors: | Sato, Y, Senda, M, Senda, T. | Deposit date: | 2017-10-10 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit Nat Commun, 9, 2018
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5CGM
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![BU of 5cgm by Molmil](/molmil-images/mine/5cgm) | Structure of Mycobacterium thermoresistibile GlgE in complex with maltose at 1.95A resolution | Descriptor: | 1,2-ETHANEDIOL, Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, CHLORIDE ION, ... | Authors: | Mendes, V, Blaszczyk, M, Maranha, A, Empadinhas, N, Blundell, T.L. | Deposit date: | 2015-07-09 | Release date: | 2015-12-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism. Sci Rep, 5, 2015
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5CIM
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![BU of 5cim by Molmil](/molmil-images/mine/5cim) | Structure of Mycobacterium thermoresistibile GlgE in complex with maltose (cocrystallisation with maltose-1-phosphate) at 3.32A resolution | Descriptor: | Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Mendes, V, Blaszczyk, M, Maranha, A, Empadinhas, N, Blundell, T.L. | Deposit date: | 2015-07-13 | Release date: | 2015-12-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism. Sci Rep, 5, 2015
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1WI1
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![BU of 1wi1 by Molmil](/molmil-images/mine/1wi1) | Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS) | Descriptor: | calcium-dependent activator protein for secretion, CAPS | Authors: | Yoneyama, M, Izumi, K, Yoshida, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-05-28 | Release date: | 2004-11-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS) To be Published
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5N66
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![BU of 5n66 by Molmil](/molmil-images/mine/5n66) | Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9j | Descriptor: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Mitogen-activated protein kinase 14, ~{N}4-[[4-(cyclopropylmethyl)furan-2-yl]methyl]-2-phenyl-quinazoline-4,7-diamine | Authors: | Buehrmann, M, Mueller, M.P, Wiedemann, B, Rauh, D. | Deposit date: | 2017-02-14 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38 alpha MAPK. PLoS ONE, 12, 2017
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5GVT
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![BU of 5gvt by Molmil](/molmil-images/mine/5gvt) | |
6PTJ
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![BU of 6ptj by Molmil](/molmil-images/mine/6ptj) | Structure of Ctf4 trimer in complex with one CMG helicase | Descriptor: | Cell division control protein 45, DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | Deposit date: | 2019-07-15 | Release date: | 2019-11-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
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6PTO
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![BU of 6pto by Molmil](/molmil-images/mine/6pto) | Structure of Ctf4 trimer in complex with three CMG helicases | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | Deposit date: | 2019-07-16 | Release date: | 2019-11-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
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6HHQ
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![BU of 6hhq by Molmil](/molmil-images/mine/6hhq) | Crystal structure of compound C45 bound to the yeast 80S ribosome | Descriptor: | (3~{R})-3-[(1~{S})-2-[(1~{S},4~{a}~{R},6~{S},7~{S},8~{a}~{R})-6,7-bis(chloranyl)-5,5,8~{a}-trimethyl-2-methylidene-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione, 18S ribosomal RNA, 25S ribosomal RNA, ... | Authors: | Pellegrino, S, Vanderwal, C.D, Yusupov, M. | Deposit date: | 2018-08-28 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.10000038 Å) | Cite: | Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome. Nucleic Acids Res., 47, 2019
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7F8T
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![BU of 7f8t by Molmil](/molmil-images/mine/7f8t) | Re-refinement of the 2XRY X-ray structure of archaeal class II CPD photolyase from Methanosarcina mazei | Descriptor: | Deoxyribodipyrimidine photolyase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Maestre-Reyna, M, Yang, C.-H, Huang, W.C, Nango, E, Gusti-Ngurah-Putu, E.-P, Franz-Badur, S, Wu, W.-J, Wu, H.-Y, Wang, P.-H, Liao, J.-H, Lee, C.-C, Huang, K.-F, Chang, Y.-K, Weng, J.-H, Sugahara, M, Owada, S, Joti, Y, Tanaka, R, Tono, K, Kiontke, S, Yamamoto, J, Iwata, S, Essen, L.-O, Bessho, Y, Tsai, M.-D. | Deposit date: | 2021-07-02 | Release date: | 2022-03-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme. Nat.Chem., 14, 2022
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5GOX
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![BU of 5gox by Molmil](/molmil-images/mine/5gox) | Eukaryotic Rad50 Functions as A Rod-shaped Dimer | Descriptor: | DNA repair protein RAD50, GLYCEROL, ZINC ION | Authors: | Park, Y.B, Hohl, M, Padjasek, M, Jeong, E, Jin, K.S, Krezel, A, Petrini, J.H.J, Cho, Y. | Deposit date: | 2016-07-30 | Release date: | 2017-02-01 | Last modified: | 2017-03-15 | Method: | X-RAY DIFFRACTION (2.405 Å) | Cite: | Eukaryotic Rad50 functions as a rod-shaped dimer Nat. Struct. Mol. Biol., 24, 2017
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1X2J
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![BU of 1x2j by Molmil](/molmil-images/mine/1x2j) | Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2 | Descriptor: | Kelch-like ECH-associated protein 1, SULFATE ION | Authors: | Padmanabhan, B, Tong, K.I, Nakamura, Y, Ohta, T, Scharlock, M, Kobayashi, A, Ohtsuji, M, Kang, M.-I, Yamamoto, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-04-25 | Release date: | 2006-03-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer Mol.Cell, 21, 2006
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1X2R
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![BU of 1x2r by Molmil](/molmil-images/mine/1x2r) | Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2 | Descriptor: | Kelch-like ECH-associated protein 1, Nuclear factor erythroid 2 related factor 2, SULFATE ION | Authors: | Padmanabhan, B, Tong, K.I, Nakamura, Y, Ohta, T, Scharlock, M, Kobayashi, A, Ohtsuji, M, Kang, M.-I, Yamamoto, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-04-26 | Release date: | 2006-03-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer Mol.Cell, 21, 2006
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5Y2O
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![BU of 5y2o by Molmil](/molmil-images/mine/5y2o) | Structure of PPARgamma ligand binding domain-pioglitazone complex | Descriptor: | (5S)-5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma | Authors: | Im, Y.J, Lee, M. | Deposit date: | 2017-07-26 | Release date: | 2017-12-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Structures of PPAR gamma complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs Sci Rep, 7, 2017
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6FFC
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![BU of 6ffc by Molmil](/molmil-images/mine/6ffc) | Structure of an inhibitor-bound ABC transporter | Descriptor: | ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate | Authors: | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | Deposit date: | 2018-01-06 | Release date: | 2018-04-11 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
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