1X2J

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2

Summary for 1X2J

Entry DOI	10.2210/pdb1x2j/pdb
Related	1X2R
Descriptor	Kelch-like ECH-associated protein 1, SULFATE ION (3 entities in total)
Functional Keywords	beta propeller, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm: Q9Z2X8
Total number of polymer chains	1
Total formula weight	35480.41
Authors	Padmanabhan, B.,Tong, K.I.,Nakamura, Y.,Ohta, T.,Scharlock, M.,Kobayashi, A.,Ohtsuji, M.,Kang, M.-I.,Yamamoto, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2005-04-25, release date: 2006-03-07, Last modification date: 2024-03-13)
Primary citation	Padmanabhan, B.,Tong, K.I.,Ohta, T.,Nakamura, Y.,Scharlock, M.,Ohtsuji, M.,Kang, M.-I.,Kobayashi, A.,Yokoyama, S.,Yamamoto, M. Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer Mol.Cell, 21:689-700, 2006 Cited by PubMed: 16507366 DOI: 10.1016/j.molcel.2006.01.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation