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1X2J

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2

Functional Information from GO Data
ChainGOidnamespacecontents
A0008134molecular_functiontranscription factor binding
A0016567biological_processprotein ubiquitination
A0031463cellular_componentCul3-RING ubiquitin ligase complex
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 701
ChainResidue
AHIS424
AGLU444
APRO445
AGLU446
AARG447
AHOH776
AHOH804
AHOH1017
AHOH1047

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 702
ChainResidue
AILE421
AASP422
AHIS424
ATYR426
AARG442
APRO492
AHOH772
AHOH818
AHOH942

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 703
ChainResidue
AARG442
AARG447
AHOH942
AHOH944
AHOH1035

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SO4 A 704
ChainResidue
AILE435
AHIS437
ASER438
ASER439
AARG494
AHOH733
AHOH744
AHOH765
AHOH778
AHOH791

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 705
ChainResidue
ACYS434
AHIS436
AARG459
AARG494
AARG498
AHOH785
AHOH875

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 706
ChainResidue
AHIS451
ALEU452
AHOH891
AHOH897
AHOH930
AHOH1009

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 707
ChainResidue
AARG380
AASN382
AASN414
AHOH748
AHOH922
AHOH936

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 708
ChainResidue
AALA407
ASER408
AHOH795
AHOH820
AHOH1038

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Sensor for electrophilic agents => ECO:0000269|PubMed:20498371
ChainResidueDetails
ACYS434

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: S-(2-succinyl)cysteine => ECO:0000269|PubMed:22014577
ChainResidueDetails
ACYS319
ACYS613

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: S-cGMP-cysteine => ECO:0000269|PubMed:20498371
ChainResidueDetails
ACYS434

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PDB entries from 2025-06-11

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