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PDB: 51630 件

8RP8
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Structure of K2 Fab in complex with human CD47 ECD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Laursen, M, Kelpsas, V, Rose, N.
登録日2024-01-12
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1.
Mabs, 16, 2024
6Z1G
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BU of 6z1g by Molmil
CryoEM structure of the interaction between Rubisco Activase small-subunit-like (SSUL) domain with Rubisco from Nostoc sp. (strain PCC7120)
分子名称: Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain, Ribulose bisphosphate carboxylase/oxygenase activase
著者Wang, H, Bracher, A, Flecken, M, Popilka, L, Hartl, F.U, Hayer-Hartl, M.
登録日2020-05-13
公開日2020-09-23
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (8.2 Å)
主引用文献Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes.
Cell, 183, 2020
8RUL
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Structure of Oceanobacillus iheyensis group II intron in the presence of Li+ and Mg2+
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Domains 1-5, MAGNESIUM ION
著者Silvestri, I, Marcia, M.
登録日2024-01-31
公開日2024-06-19
最終更新日2024-07-03
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.
Nat Commun, 15, 2024
8RUH
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Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+ and 5'-exon
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-exon, Domains 1-5, ...
著者Silvestri, I, Marcia, M.
登録日2024-01-30
公開日2024-06-19
最終更新日2024-07-03
実験手法X-RAY DIFFRACTION (4.55 Å)
主引用文献Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.
Nat Commun, 15, 2024
8S3R
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HUMAN PI3KDELTA IN COMPLEX WITH PYRIDAZINONE INHIBITOR 7
分子名称: 5-[(1~{S})-1-[4-azanyl-3-(5-oxidanylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-cyclopentyl-2-(phenylmethyl)pyridazin-3-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Pala, D, Bruno, P, Capelli, A.M, Biagetti, M.
登録日2024-02-20
公開日2024-07-03
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Discovery and Optimization of Pyridazinones as PI3K delta Selective Inhibitors for Administration by Inhalation.
J.Med.Chem., 67, 2024
5ZCS
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BU of 5zcs by Molmil
4.9 Angstrom Cryo-EM structure of human mTOR complex 2
分子名称: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ...
著者Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y.
登録日2018-02-20
公開日2018-03-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献Cryo-EM structure of human mTOR complex 2.
Cell Res., 28, 2018
8RUM
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BU of 8rum by Molmil
Structure of Oceanobacillus iheyensis group II intron in the presence of Li+, Mg2+, and intronistat B
分子名称: Domains 1-5, MAGNESIUM ION, ~{N}-(2-pyrrolidin-1-ylethyl)-2-[3,4,5-tris(oxidanyl)phenyl]carbonyl-1-benzofuran-5-carboxamide
著者Silvestri, I, Marcia, M.
登録日2024-01-31
公開日2024-06-19
最終更新日2024-07-03
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.
Nat Commun, 15, 2024
6WQA
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2.0A angstrom A2a adenosine receptor structure using XFEL data collected in helium atmosphere.
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ...
著者Lee, M.-Y, Geiger, J, Ishchenko, A, Han, G.W, Barty, A, White, T.A, Gati, C, Batyuk, A, Hunter, M.S, Aquila, A, Boutet, S, Weierstall, U, Cherezov, V, Liu, W.
登録日2020-04-28
公開日2020-11-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase
Iucrj, 7, 2020
6QP3
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BU of 6qp3 by Molmil
Crystal structure of the PLP-bound C-S lyase from Bacillus subtilis (strain 168)
分子名称: ACETATE ION, Cystathionine beta-lyase PatB, PYRIDOXAL-5'-PHOSPHATE
著者Herman, R, Rudden, M, Wilkinson, A.J, Hanai, S, Thomas, G.H.
登録日2019-02-13
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The molecular basis of thioalcohol production in human body odour.
Sci Rep, 10, 2020
6QW5
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Structure and function of the toscana virus cap snatching endonuclease
分子名称: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, RNA-dependent RNA polymerase, ...
著者Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M.
登録日2019-03-05
公開日2019-09-25
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.988 Å)
主引用文献Structure and function of the Toscana virus cap-snatching endonuclease.
Nucleic Acids Res., 47, 2019
8S7Z
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BU of 8s7z by Molmil
Urethanase umg-sp1 without inhibitor or substrate displays flexible active site loops
分子名称: Urethanase umg-sp1
著者Palm, G.J, Graf, L.G, Berndt, L, Lammers, M.
登録日2024-03-05
公開日2024-07-24
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural Elucidation of a Metagenomic Urethanase and Its Engineering Towards Enhanced Hydrolysis Profiles.
Angew.Chem.Int.Ed.Engl., 2024
6ZDR
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BU of 6zdr by Molmil
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 4d
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ...
著者Verdon, G, Jespers, W, Azuaje, J, Majellaro, M, Keranen, H, Garcia-mera, X, Congreve, M, Deflorian, F, de Graaf, C, Zhukov, A, Dore, A, Mason, J, Aqvist, J, Cooke, R, Sotelo, E, Gutierrez-de-Teran, H.
登録日2020-06-15
公開日2020-09-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.918 Å)
主引用文献X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists.
Angew.Chem.Int.Ed.Engl., 59, 2020
6QMH
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BU of 6qmh by Molmil
Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 3-(1H-indol-3-yl)propanoic acid at 1.6A resolution.
分子名称: 5-[3-(1~{H}-indol-3-yl)propoxy]-1-phenyl-pyrazole-4-carboxylic acid, Phosphopantetheine adenylyltransferase
著者Blaszczyk, M, Blundell, T.L.
登録日2019-02-07
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.837 Å)
主引用文献Fragment linking applied to the discovery of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase inhibitors
To Be Published
3AUP
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BU of 3aup by Molmil
Crystal structure of Basic 7S globulin from soybean
分子名称: Basic 7S globulin
著者Yoshizawa, T, Shimizu, T, Taichi, M, Nishiuchi, Y, Yamabe, M, Shichijo, N, Unzai, S, Hirano, H, Sato, M, Hashimoto, H.
登録日2011-02-14
公開日2011-04-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal structure of basic 7S globulin, a xyloglucan-specific endo-beta-1,4-glucanase inhibitor protein-like protein from soybean lacking inhibitory activity against endo-beta-glucanase
Febs J., 278, 2011
3APD
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BU of 3apd by Molmil
Crystal structure of human PI3K-gamma in complex with CH5108134
分子名称: 5-(2-Morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者Nakamura, M, Fukami, T.A, Miyazaki, T, Yoshida, M.
登録日2010-10-14
公開日2011-04-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799
Bioorg.Med.Chem.Lett., 21, 2011
6Z2G
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BU of 6z2g by Molmil
Crystal structure of human NLRP9 PYD
分子名称: NACHT, LRR and PYD domains-containing protein 9
著者Marleaux, M, Anand, K, Geyer, M.
登録日2020-05-15
公開日2020-06-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.
Febs Lett., 594, 2020
6QP1
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BU of 6qp1 by Molmil
Crystal structure of the PLP-bound C-S lyase in the external aldimine form from Staphylococcus hominis complexed with an inhibitor, L-cycloserine.
分子名称: Aminotransferase, [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate
著者Herman, R, Rudden, M, Wilkinson, A.J, Hanai, S, Thomas, G.H.
登録日2019-02-13
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献The molecular basis of thioalcohol production in human body odour.
Sci Rep, 10, 2020
8SDH
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BU of 8sdh by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.56
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neutralizing antibody CC25.56 Heavy Chain, ...
著者Yuan, M, Wilson, I.A.
登録日2023-04-06
公開日2024-08-07
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift.
Biorxiv, 2023
5Z2H
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BU of 5z2h by Molmil
Structure of Dictyostelium discoideum mitochondrial calcium uniporter N-terminal domain(DdMCU-NTD)
分子名称: Dictyostelium discoideum mitochondrial calcium uniporter
著者Yuan, Y, Wen, M, Chou, J.J, Li, D, Bo, O.
登録日2018-01-02
公開日2019-01-02
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.674 Å)
主引用文献Structural Characterization of the N-Terminal Domain of theDictyostelium discoideumMitochondrial Calcium Uniporter.
Acs Omega, 5, 2020
5HF5
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BU of 5hf5 by Molmil
Crystal structure of human acetylcholinesterase in complex with paraoxon in the unaged state (predominant acyl loop conformation)
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Franklin, M.F, Rudolph, M.J, Ginter, C, Cassidy, M.S, Cheung, J.
登録日2016-01-06
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.152 Å)
主引用文献Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface.
Proteins, 84, 2016
3APC
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BU of 3apc by Molmil
Crystal structure of human PI3K-gamma in complex with CH5132799
分子名称: 5-(7-Methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者Nakamura, M, Fukami, T.A, Miyazaki, T, Yoshida, M.
登録日2010-10-14
公開日2011-04-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.544 Å)
主引用文献Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799
Bioorg.Med.Chem.Lett., 21, 2011
5HMC
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BU of 5hmc by Molmil
Crystal structure of S. sahachiroi AziG complexed with 5-methyl naphthoic acid
分子名称: 5-methylnaphthalene-1-carboxylic acid, Azi13, SULFATE ION
著者Zhang, Y, Erb, M.S, Ealick, S.E.
登録日2016-01-15
公開日2016-02-03
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.
Biochemistry, 55, 2016
5VXZ
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BU of 5vxz by Molmil
High-affinity AXL decoy receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Mathrews, I.I, Kapur, S, Kariolis, M.S, Cochran, J.R.
登録日2017-05-24
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
J. Clin. Invest., 127, 2017
5HII
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BU of 5hii by Molmil
Crystal structure of glycine sarcosine N-methyltransferase (GSMT) from Methanohalophilus portucalensis (apo form)
分子名称: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-01-12
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
8TPJ
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BU of 8tpj by Molmil
Top cylinder bound to OCP from high-resolution phycobilisome quenched by OCP (local refinement)
分子名称: Allophycocyanin alpha chain, Allophycocyanin beta chain, Orange carotenoid-binding protein, ...
著者Sauer, P.V, Sutter, M, Cupellini, L.
登録日2023-08-04
公開日2024-04-17
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
Sci Adv, 10, 2024

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件を2024-08-28に公開中

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