6ZDR

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 4d

Summary for 6ZDR

Entry DOI	10.2210/pdb6zdr/pdb
Descriptor	Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, [3-(4-methyl-1,3-thiazol-2-yl)-4-oxidanylidene-6-propyl-chromen-7-yl] ethanoate, SODIUM ION, ... (7 entities in total)
Functional Keywords	g protein-coupled receptor, membrane protein, receptor, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	54056.33
Authors	Verdon, G.,Jespers, W.,Azuaje, J.,Majellaro, M.,Keranen, H.,Garcia-mera, X.,Congreve, M.,Deflorian, F.,de Graaf, C.,Zhukov, A.,Dore, A.,Mason, J.,Aqvist, J.,Cooke, R.,Sotelo, E.,Gutierrez-de-Teran, H. (deposition date: 2020-06-15, release date: 2020-09-16, Last modification date: 2024-01-24)
Primary citation	Jespers, W.,Verdon, G.,Azuaje, J.,Majellaro, M.,Keranen, H.,Garcia-Mera, X.,Congreve, M.,Deflorian, F.,de Graaf, C.,Zhukov, A.,Dore, A.S.,Mason, J.S.,Aqvist, J.,Cooke, R.M.,Sotelo, E.,Gutierrez-de-Teran, H. X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists. Angew.Chem.Int.Ed.Engl., 59:16536-16543, 2020 Cited by PubMed: 32542862 DOI: 10.1002/anie.202003788 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.918 Å)

Structure validation