6QMH

Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 3-(1H-indol-3-yl)propanoic acid at 1.6A resolution.

Replaces:  6G7T

Summary for 6QMH

• Entry DOI: 10.2210/pdb6qmh/pdb
• Descriptor: Phosphopantetheine adenylyltransferase, 5-[3-(1~{H}-indol-3-yl)propoxy]-1-phenyl-pyrazole-4-carboxylic acid (3 entities in total)
• Functional Keywords: coad, ppat, transferase, complex
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 18153.78

Authors

Blaszczyk, M.,Blundell, T.L. (deposition date: 2019-02-07, release date: 2020-02-26, Last modification date: 2024-01-24)

• Primary citation: Blaszczyk, M.,El Bakali, J.,Boland, J.A.,Spry, C.,Dias, M.,Blundell, T.L.,Abel, C.; Fragment linking applied to the discovery of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.837 Å)