5VXZ

High-affinity AXL decoy receptor

Summary for 5VXZ

Entry DOI	10.2210/pdb5vxz/pdb
Descriptor	Growth arrest-specific protein 6, Tyrosine-protein kinase receptor UFO, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	engineered decoy receptor, human cancers, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	111257.46
Authors	Mathrews, I.I.,Kapur, S.,Kariolis, M.S.,Cochran, J.R. (deposition date: 2017-05-24, release date: 2017-06-21, Last modification date: 2023-10-04)
Primary citation	Kariolis, M.S.,Miao, Y.R.,Diep, A.,Nash, S.E.,Olcina, M.M.,Jiang, D.,Jones, D.S.,Kapur, S.,Mathews, I.I.,Koong, A.C.,Rankin, E.B.,Cochran, J.R.,Giaccia, A.J. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J. Clin. Invest., 127:183-198, 2017 Cited by PubMed: 27893463 DOI: 10.1172/JCI85610 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation