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PDB: 264 results

2N68
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BU of 2n68 by Molmil
Solution study of Astexin1
Descriptor: astexin1
Authors:Link, A.J, Maksimov, M.O.
Deposit date:2015-08-13
Release date:2015-11-04
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Construction of Lasso Peptide Fusion Proteins.
Acs Chem.Biol., 11, 2016
2N6V
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BU of 2n6v by Molmil
Solution study of Astexin3
Descriptor: ASTEXIN3
Authors:Link, A, Maksimov, M.O.
Deposit date:2015-08-28
Release date:2015-11-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase.
J.Biol.Chem., 290, 2015
2N6U
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BU of 2n6u by Molmil
Solution study of Astexin2-dC4
Descriptor: Astexin2-dC4
Authors:Link, A, Maksimov, M.O.
Deposit date:2015-08-28
Release date:2015-11-11
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase.
J.Biol.Chem., 290, 2015
2O7H
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BU of 2o7h by Molmil
Crystal structure of trimeric coiled coil GCN4 leucine zipper
Descriptor: General control protein GCN4
Authors:Jawhari, H, Honnappa, S, Steinmetz, M.O.
Deposit date:2006-12-11
Release date:2007-11-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Molecular basis of coiled-coil oligomerization-state specificity
Proc.Natl.Acad.Sci.USA, 107, 2010
2PZI
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BU of 2pzi by Molmil
Crystal Structure of Protein kinase PknG from Mycobacterium tuberculosis in Complex with Tetrahydrobenzothiophene AX20017
Descriptor: 2-[(CYCLOPROPYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE, CADMIUM ION, CHLORIDE ION, ...
Authors:Honnappa, S, Steinmetz, M.O.
Deposit date:2007-05-18
Release date:2007-07-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 104, 2007
7Z7D
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BU of 7z7d by Molmil
Tubulin-Todalam-Vinblastine-complex
Descriptor: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2022-03-15
Release date:2022-04-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
7Z2P
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BU of 7z2p by Molmil
Tubulin-nocodazole complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Prota, A.E, Muehlethaler, T, Cavalli, A, Steinmetz, M.O.
Deposit date:2022-02-28
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.
Eur.J.Med.Chem., 241, 2022
7Z2N
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BU of 7z2n by Molmil
Tubulin-18-complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Muehlethaler, T, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2022-02-28
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.
Eur.J.Med.Chem., 241, 2022
7ZCW
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BU of 7zcw by Molmil
Cryo-EM structure of GMPCPP-microtubules in complex with VASH2-SVBP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Choi, S.R, Blum, T, Steinmetz, M.O.
Deposit date:2022-03-29
Release date:2022-12-14
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules.
J.Cell Biol., 222, 2023
6F9Q
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BU of 6f9q by Molmil
Binary complex of a 7S-cis-cis-nepetalactol cyclase from Nepeta mussinii with NAD+
Descriptor: 7S-cis-cis-nepetalactol cyclase, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lichman, B.R, Kamileen, M.O, Titchiner, G, Saalbach, G, Stevenson, C.E.M, Lawson, D.M, O'Connor, S.E.
Deposit date:2017-12-15
Release date:2018-12-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.
Nat. Chem. Biol., 15, 2019
6FC5
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BU of 6fc5 by Molmil
Bik1 CAP-Gly domain
Descriptor: Microtubule-associated protein
Authors:Kumar, A, Stangier, M.M, Steinmetz, M.O.
Deposit date:2017-12-20
Release date:2018-04-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure-Function Relationship of the Bik1-Bim1 Complex.
Structure, 26, 2018
1SD0
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BU of 1sd0 by Molmil
Structure of arginine kinase C271A mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ARGININE, Arginine kinase, ...
Authors:Gattis, J.L, Ruben, E, Fenley, M.O, Ellington, W.R, Chapman, M.S.
Deposit date:2004-02-12
Release date:2004-07-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The active site cysteine of arginine kinase: structural and functional analysis of partially active mutants
Biochemistry, 43, 2004
6FJM
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BU of 6fjm by Molmil
tubulin-Disorazole Z complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Disorazole Z, ...
Authors:Menchon, G, Prota, A.E, Lucena Agell, D, Bucher, P, Jansen, R, Irschik, H, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6F7C
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BU of 6f7c by Molmil
TUBULIN-Compound 12 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,4,5-trimethoxy-~{N}-[(~{E})-naphthalen-1-ylmethylideneamino]benzamide, CALCIUM ION, ...
Authors:Muehlethaler, T, Prota, A.E, Steinmetz, M.O.
Deposit date:2017-12-08
Release date:2018-12-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.
Iscience, 21, 2019
6FC6
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BU of 6fc6 by Molmil
Bik1 CAP-Gly domain with ETF peptide from Bim1
Descriptor: Nuclear fusion protein BIK1, Protein BIM1
Authors:Kumar, A, Stangier, M.M, Steinmetz, M.O.
Deposit date:2017-12-20
Release date:2018-04-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-Function Relationship of the Bik1-Bim1 Complex.
Structure, 26, 2018
6FII
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BU of 6fii by Molmil
Tubulin-Spongistatin complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
Deposit date:2018-01-18
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6FJS
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BU of 6fjs by Molmil
Proteinase~K SIRAS phased structure of room-temperature, serially collected synchrotron data
Descriptor: CALCIUM ION, Proteinase K
Authors:Botha, S, Baitan, D, Jungnickel, K.E.J, Oberthuer, D, Schmidt, C, Stern, S, Wiedorn, M.O, Perbandt, M, Chapman, H.N, Betzel, C.
Deposit date:2018-01-23
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:De novoprotein structure determination by heavy-atom soaking in lipidic cubic phase and SIRAS phasing using serial synchrotron crystallography.
IUCrJ, 5, 2018
6FKJ
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BU of 6fkj by Molmil
Tubulin-TUB075 complex
Descriptor: (5~{S})-2-[(~{E})-~{N}-(2-ethoxyphenyl)-~{C}-methyl-carbonimidoyl]-3-oxidanyl-5-phenyl-cyclohex-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Prota, A.E, Steinmetz, M.O, Priego, E.-M.
Deposit date:2018-01-24
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.
Sci Rep, 8, 2018
6FX7
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BU of 6fx7 by Molmil
Crystal structure of in vitro evolved Af1521
Descriptor: [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, [Protein ADP-ribosylglutamate] hydrolase AF_1521
Authors:Karlberg, T, Thorsell, A.G, Nowak, K, Hottiger, M.O, Schuler, H.
Deposit date:2018-03-08
Release date:2019-09-25
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.
Nat Commun, 11, 2020
6GF3
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BU of 6gf3 by Molmil
Tubulin-Jerantinine B acetate complex
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Smedley, C.J, Stanley, P.A, Qazzaz, M.E, Prota, A.E, Olieric, N, Collins, H, Eastman, H, Barrow, A.S, Lim, K.-H, Kam, T.-S, Smith, B.J, Duivenvoorden, H.M, Parker, B.S, Bradshaw, T.D, Steinmetz, M.O, Moses, J.E.
Deposit date:2018-04-29
Release date:2019-05-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.
Sci Rep, 8, 2018
6FLJ
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BU of 6flj by Molmil
Crystal structure of Cep120 C2A_K76A mutant
Descriptor: Centrosomal protein of 120 kDa
Authors:Sharma, A, Gerard, S.F, Olieric, N, Steinmetz, M.O.
Deposit date:2018-01-26
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Cep120 promotes microtubule formation through a unique tubulin binding C2 domain.
J. Struct. Biol., 203, 2018
6FJF
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BU of 6fjf by Molmil
Tubulin-FcMaytansine complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6FKL
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BU of 6fkl by Molmil
Tubulin-TUB015 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{1-[(2-Methoxyphenyl)amino]ethylidene}-5-phenyl-1,3-cyclohexanedione, CALCIUM ION, ...
Authors:Prota, A.E, Steinmetz, M.O, Priego, E.-M.
Deposit date:2018-01-24
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.
Sci Rep, 8, 2018
6FLK
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BU of 6flk by Molmil
Crystal structure of Cep120 C2C domain
Descriptor: Cep120
Authors:Sharma, A, Gerard, S.F, Olieric, N, Steinmetz, M.O.
Deposit date:2018-01-26
Release date:2018-02-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Cep120 promotes microtubule formation through a unique tubulin binding C2 domain.
J. Struct. Biol., 203, 2018
6GZC
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BU of 6gzc by Molmil
heterotetrameric katanin p60:p80 complex
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Katanin p60 ATPase-containing subunit A1, ...
Authors:Faltova, L, Jiang, K, Frey, D, Wu, Y, Capitani, G, Prota, A.E, Akhmanova, A, Steinmetz, M.O, Kammerer, R.A.
Deposit date:2018-07-03
Release date:2019-08-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex.
Structure, 27, 2019

221051

数据于2024-06-12公开中

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