8C0F

Tubulin-PTC596 complex

Summary for 8C0F

• Entry DOI: 10.2210/pdb8c0f/pdb
• Descriptor: Tubulin alpha-1B chain, GLYCEROL, 5-fluoranyl-2-(6-fluoranyl-2-methyl-benzimidazol-1-yl)-~{N}4-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine, ... (15 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265478.17

Authors

Prota, A.E.,Muehlethaler, T.,Weetall, M.,Steinmetz, M.O. (deposition date: 2022-12-16, release date: 2022-12-28, Last modification date: 2024-02-07)

• Primary citation: Jernigan, F.,Branstrom, A.,Baird, J.D.,Cao, L.,Dali, M.,Furia, B.,Kim, M.J.,O'Keefe, K.,Kong, R.,Laskin, O.L.,Colacino, J.M.,Pykett, M.,Mollin, A.,Sheedy, J.,Dumble, M.,Moon, Y.-C.,Sheridan, R.,Muehlethaler, T.,Spiegel, R.J.,Prota, A.E.,Steinmetz, M.O.,Weetall, M.; Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent; Mol Cancer Ther, 20:1846-1857, 2021; PubMed: 34315764; DOI: 10.1158/1535-7163.MCT-20-0774

Experimental method

X-RAY DIFFRACTION (2.1005 Å)