5SB7

Tubulin-todalam-18-complex

Summary for 5SB7

Entry DOI	10.2210/pdb5sb7/pdb
Group deposition	Todalam compounds complexed with T2R-TTL (G_1002214)
Descriptor	Tubulin alpha-1B chain, N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	6
Total formula weight	264923.75
Authors	Muehlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O. (deposition date: 2021-07-08, release date: 2022-04-27, Last modification date: 2024-05-22)
Primary citation	Muhlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Roy, B.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O. Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew.Chem.Int.Ed.Engl., 61:e202204052-e202204052, 2022 Cited by PubMed: 35404502 DOI: 10.1002/anie.202204052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation