8P4J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p4j by Molmil](/molmil-images/mine/8p4j) | Alpha-1-antitrypsin - Sydney variant (G192C) | Descriptor: | Alpha-1-antitrypsin | Authors: | Kamuda, K, Lomas, D.A, Irving, J.A. | Deposit date: | 2023-05-22 | Release date: | 2024-04-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. Febs J., 291, 2024
|
|
8P4U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p4u by Molmil](/molmil-images/mine/8p4u) | Alpha-1-antitrypsin - Sydney variant (G192C) | Descriptor: | Alpha-1-antitrypsin | Authors: | Kamuda, K, Lomas, D.A, Irving, J.A. | Deposit date: | 2023-05-23 | Release date: | 2024-04-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. Febs J., 291, 2024
|
|
6ROD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6rod by Molmil](/molmil-images/mine/6rod) | |
6I1O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i1o by Molmil](/molmil-images/mine/6i1o) | Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FAB 2H2 heavy chain, FAB 2H2 light chain, ... | Authors: | Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Fra, A, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-10-29 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5, 2020
|
|
6I3Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i3z by Molmil](/molmil-images/mine/6i3z) | Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen | Descriptor: | Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ... | Authors: | Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Fra, A, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-11-08 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5, 2020
|
|
6IAY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6iay by Molmil](/molmil-images/mine/6iay) | |
6I7U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i7u by Molmil](/molmil-images/mine/6i7u) | |
6I4V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i4v by Molmil](/molmil-images/mine/6i4v) | |
6HX4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hx4 by Molmil](/molmil-images/mine/6hx4) | Fab fragment of a native monomer-selective antibody in complex with alpha-1-antitrypsin | Descriptor: | Alpha-1-antitrypsin, Fab 1D9 heavy chain, Fab 1D9 light chain | Authors: | Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-10-15 | Release date: | 2019-10-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Characterisation of a monoclonal antibody conformationally-selective for native alpha-1-antitrypsin To Be Published
|
|
6QU9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qu9 by Molmil](/molmil-images/mine/6qu9) | Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin | Descriptor: | FAB 4B12 heavy chain, FAB 4B12 light chain, GLYCEROL, ... | Authors: | Jagger, A.M, Heyer-Chauhan, N, Lomas, D.A, Irving, J.A. | Deposit date: | 2019-02-26 | Release date: | 2020-03-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structural basis for Z alpha 1 -antitrypsin polymerization in the liver. Sci Adv, 6, 2020
|
|
6GXX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gxx by Molmil](/molmil-images/mine/6gxx) | Fab fragment of an antibody selective for alpha-1-antitrypsin in the native conformation | Descriptor: | FAB 1D9 heavy chain, FAB 1D9 light chain, MAGNESIUM ION | Authors: | Elliston, E.L.K, Miranda, E, Perez, J, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-06-27 | Release date: | 2019-07-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Characterisation of a monoclonal antibody conformationally-selective for native alpha-1-antitrypsin To Be Published
|
|
1R1L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1r1l by Molmil](/molmil-images/mine/1r1l) | Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide (formyl-norleucine-LF) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin P14-P9 peptide, Antithrombin-III, ... | Authors: | Zhou, A, Huntington, J.A, Lomas, D.A, Stein, P.E, Carrell, R.W. | Deposit date: | 2003-09-24 | Release date: | 2004-10-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Serpins and the design of peptides to block intermolecular beta-linkages To be Published
|
|
1BR8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1br8 by Molmil](/molmil-images/mine/1br8) | IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN | Descriptor: | PROTEIN (ANTITHROMBIN-III), PROTEIN (PEPTIDE) | Authors: | Skinner, R, Chang, W.S.W, Jin, L, Pei, X.Y, Huntington, J.A, Abrahams, J.P, Carrell, R.W, Lomas, D.A. | Deposit date: | 1998-08-26 | Release date: | 1998-09-02 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin. J.Mol.Biol., 283, 1998
|
|
1QLP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qlp by Molmil](/molmil-images/mine/1qlp) | 2.0 ANGSTROM STRUCTURE OF INTACT ALPHA-1-ANTITRYPSIN: A CANONICAL TEMPLATE FOR ACTIVE SERPINS | Descriptor: | ALPHA-1-ANTITRYPSIN | Authors: | Elliott, P.R, Pei, X.Y, Dafforn, T, Read, R.J, Carrell, R.W, Lomas, D.A. | Deposit date: | 1999-09-10 | Release date: | 1999-09-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease. Protein Sci., 9, 2000
|
|
1JVQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1jvq by Molmil](/molmil-images/mine/1jvq) | Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive loop peptide, and an exogenous tetrapeptide | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | Authors: | Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E. | Deposit date: | 2001-08-31 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | How small peptides block and reverse serpin polymerisation J.Mol.Biol., 342, 2004
|
|
1PSI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1psi by Molmil](/molmil-images/mine/1psi) | |
1QMN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qmn by Molmil](/molmil-images/mine/1qmn) | |
1QMB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qmb by Molmil](/molmil-images/mine/1qmb) | Cleaved alpha-1-antitrypsin polymer | Descriptor: | ALPHA-1-ANTITRYPSIN | Authors: | Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W. | Deposit date: | 1999-09-24 | Release date: | 2000-02-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease J.Mol.Biol., 293, 1999
|
|
3DRM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3drm by Molmil](/molmil-images/mine/3drm) | 2.2 Angstrom Crystal Structure of Thr114Phe Alpha1-Antitrypsin | Descriptor: | Alpha-1-antitrypsin | Authors: | Gooptu, B, Nobeli, I, Purkiss, A, Phillips, R.L, Mallya, M, Lomas, D.A, Barrett, T.E. | Deposit date: | 2008-07-11 | Release date: | 2009-03-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design. J.Mol.Biol., 387, 2009
|
|
3DRU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dru by Molmil](/molmil-images/mine/3dru) | Crystal Structure of Gly117Phe Alpha1-Antitrypsin | Descriptor: | Alpha-1-antitrypsin | Authors: | Gooptu, B, Nobeli, I, Purkiss, A, Phillips, R.L, Mallya, M, Lomas, D.A, Barrett, T.E. | Deposit date: | 2008-07-11 | Release date: | 2009-03-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design. J.Mol.Biol., 387, 2009
|
|
1LK6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1lk6 by Molmil](/molmil-images/mine/1lk6) | Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E. | Deposit date: | 2002-04-24 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol J.Biol.Chem., 278, 2003
|
|