6XKK
 
 | | Cryo-EM structure of the NLRP1-CARD filament | | 分子名称: | NACHT, LRR and PYD domains-containing protein 1 | | 著者 | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | | 登録日 | 2020-06-26 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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6XKJ
 | | Cryo-EM structure of CARD8-CARD filament | | 分子名称: | Caspase recruitment domain-containing protein 8 | | 著者 | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | | 登録日 | 2020-06-26 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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7KEU
 | | Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer | | 分子名称: | Apoptosis-associated speck-like protein containing a CARD, Caspase-1 | | 著者 | Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H. | | 登録日 | 2020-10-12 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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6X6C
 | | Cryo-EM structure of NLRP1-DPP9-VbP complex | | 分子名称: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ... | | 著者 | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | | 登録日 | 2020-05-27 | | 公開日 | 2021-03-10 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
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6X6A
 | | Cryo-EM structure of NLRP1-DPP9 complex | | 分子名称: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1 | | 著者 | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | | 登録日 | 2020-05-27 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
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4PX9
 | | DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X | | 著者 | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | | 登録日 | 2014-03-22 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
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4PXA
 | | DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION | | 著者 | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | | 登録日 | 2014-03-22 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
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8K8T
 | | Structure of CUL3-RBX1-KLHL22 complex | | 分子名称: | Cullin-3, Kelch-like protein 22 | | 著者 | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | | 登録日 | 2023-07-31 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
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8K9I
 | | Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | 著者 | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | | 登録日 | 2023-08-01 | | 公開日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
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7B6W
 | | Crystal structure of the human alpha1B adrenergic receptor in complex with inverse agonist (+)-cyclazosin | | 分子名称: | Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor, [(4~{a}~{R},8~{a}~{S})-4-(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)-2,3,4~{a},5,6,7,8,8~{a}-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone | | 著者 | Deluigi, M, Morstein, L, Hilge, M, Schuster, M, Merklinger, L, Klipp, A, Scott, D.J, Plueckthun, A. | | 登録日 | 2020-12-08 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.873 Å) | | 主引用文献 | Crystal structure of the alpha 1B -adrenergic receptor reveals molecular determinants of selective ligand recognition.
Nat Commun, 13, 2022
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4R7Z
 | | PfMCM-AAA double-octamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 21, MAGNESIUM ION | | 著者 | Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J. | | 登録日 | 2014-08-28 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
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4R7Y
 | | Crystal structure of an active MCM hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J. | | 登録日 | 2014-08-28 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
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2MAI
 | | NMR structure of lassomycin | | 分子名称: | Lassomycin | | 著者 | Gavrish, E, Sit, C.S, Kandror, O, Spoering, A, Peoples, A, Ling, L, Fetterman, A, Hughes, D, Cao, S, Bissell, A, Torrey, H, Akopian, T, Mueller, A, Epstein, S, Goldberg, A, Clardy, J, Lewis, K. | | 登録日 | 2013-07-09 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2.
Chem.Biol., 21, 2014
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4WMY
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4WMQ
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4XGK
 | | Crystal structure of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic | | 分子名称: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SULFATE ION, UDP-galactopyranose mutase, ... | | 著者 | Wangkanont, K, Heroux, A, Forest, K.T, Kiessling, L.L. | | 登録日 | 2014-12-31 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.652 Å) | | 主引用文献 | Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.
Acs Chem.Biol., 10, 2015
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8UV0
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4WMO
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6XTU
 | | FULL-LENGTH LTTR LYSG FROM CORYNEBACTERIUM GLUTAMICUM | | 分子名称: | Lysine export transcriptional regulatory protein LysG | | 著者 | Hofmann, E, Syberg, F, Schlicker, C, Eggeling, L, Schendzielorz, G. | | 登録日 | 2020-01-16 | | 公開日 | 2020-10-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Engineering and application of a biosensor with focused ligand specificity.
Nat Commun, 11, 2020
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6XTV
 | | FULL-LENGTH LTTR LYSG FROM CORYNEBACTERIUM GLUTAMICUM WITH BOUND EFFECTOR ARG | | 分子名称: | ARGININE, Lysine export transcriptional regulatory protein LysG | | 著者 | Hofmann, E, Syberg, F, Schlicker, C, Eggeling, L, Schendzielorz, G. | | 登録日 | 2020-01-16 | | 公開日 | 2020-10-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Engineering and application of a biosensor with focused ligand specificity.
Nat Commun, 11, 2020
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5D8N
 | | Tomato leucine aminopeptidase mutant - K354E | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | DuPrez, K.T, Scranton, M.A, Walling, L.L, Fan, L. | | 登録日 | 2015-08-17 | | 公開日 | 2016-05-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural insights into chaperone-activity enhancement by a K354E mutation in tomato acidic leucine aminopeptidase.
Acta Crystallogr D Struct Biol, 72, 2016
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4WN0
 | | Xenopus laevis embryonic epidermal lectin in complex with glycerol phosphate | | 分子名称: | CALCIUM ION, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ... | | 著者 | Wangkanont, K, Kiessling, L.L, Forest, K.T. | | 登録日 | 2014-10-10 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
J.Biol.Chem., 291, 2016
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8E1X
 | | FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29) | | 分子名称: | (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2 | | 著者 | Lei, H.-T, Epling, L.B, Deller, M.C. | | 登録日 | 2022-08-11 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
J.Med.Chem., 65, 2022
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4XAD
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4XJJ
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