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PDB: 86 件
7KEU
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BU of 7keu by Molmil
Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer
分子名称: Apoptosis-associated speck-like protein containing a CARD, Caspase-1
著者Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H.
登録日2020-10-12
公開日2020-11-25
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6XKK
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BU of 6xkk by Molmil
Cryo-EM structure of the NLRP1-CARD filament
分子名称: NACHT, LRR and PYD domains-containing protein 1
著者Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
登録日2020-06-26
公開日2020-11-25
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6XKJ
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BU of 6xkj by Molmil
Cryo-EM structure of CARD8-CARD filament
分子名称: Caspase recruitment domain-containing protein 8
著者Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
登録日2020-06-26
公開日2020-11-25
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
4PXA
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BU of 4pxa by Molmil
DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION
著者Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
登録日2014-03-22
公開日2015-03-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
4PX9
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BU of 4px9 by Molmil
DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X
著者Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
登録日2014-03-22
公開日2015-03-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
6X6C
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BU of 6x6c by Molmil
Cryo-EM structure of NLRP1-DPP9-VbP complex
分子名称: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ...
著者Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
登録日2020-05-27
公開日2021-03-10
最終更新日2021-05-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6X6A
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BU of 6x6a by Molmil
Cryo-EM structure of NLRP1-DPP9 complex
分子名称: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1
著者Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
登録日2020-05-27
公開日2021-03-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
8K8T
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BU of 8k8t by Molmil
Structure of CUL3-RBX1-KLHL22 complex
分子名称: Cullin-3, Kelch-like protein 22
著者Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y.
登録日2023-07-31
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
8K9I
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Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif
分子名称: Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ...
著者Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y.
登録日2023-08-01
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
2MAI
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BU of 2mai by Molmil
NMR structure of lassomycin
分子名称: Lassomycin
著者Gavrish, E, Sit, C.S, Kandror, O, Spoering, A, Peoples, A, Ling, L, Fetterman, A, Hughes, D, Cao, S, Bissell, A, Torrey, H, Akopian, T, Mueller, A, Epstein, S, Goldberg, A, Clardy, J, Lewis, K.
登録日2013-07-09
公開日2014-05-07
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2.
Chem.Biol., 21, 2014
4WMY
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BU of 4wmy by Molmil
Structure of Human intelectin-1 in complex with allyl-beta-galactofuranose
分子名称: CALCIUM ION, Intelectin-1, prop-2-en-1-yl beta-D-galactofuranoside
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2014-10-09
公開日2015-07-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Recognition of microbial glycans by human intelectin-1.
Nat.Struct.Mol.Biol., 22, 2015
4WMO
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BU of 4wmo by Molmil
Selenomethionine derivative of Xenopus laevis embryonic epidermal lectin carbohydrate-binding domain
分子名称: CALCIUM ION, PENTAETHYLENE GLYCOL, XEEL protein
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2014-10-09
公開日2016-01-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
J.Biol.Chem., 291, 2016
5EQF
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BU of 5eqf by Molmil
Crystal structure of oxidized UDP-galactopyranose mutase from Corynebacterium diphtheriae with UDP bound in closed form
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, UDP-galactopyranose mutase, ...
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2015-11-12
公開日2016-11-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.145 Å)
主引用文献Conformational Control of UDP-Galactopyranose Mutase Inhibition.
Biochemistry, 56, 2017
5EQD
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BU of 5eqd by Molmil
Structure of oxidized UDP-galactopyranose mutase from Mycobacterium smegmatis in complex with UDP in opened and closed form
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, NITRATE ION, SULFATE ION, ...
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2015-11-12
公開日2016-11-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structural dynamics of UDP-galactopyranose mutase from Mycobacterium smegmatis
to be published
2QW1
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BU of 2qw1 by Molmil
Glucose/galactose binding protein bound to 3-O-methyl D-glucose
分子名称: 3-O-methyl-beta-D-glucopyranose, CALCIUM ION, D-galactose-binding periplasmic protein, ...
著者Borrok, M.J, Kiessling, L.L, Forest, K.T.
登録日2007-08-09
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure-based design of a periplasmic binding protein antagonist that prevents domain closure.
Acs Chem.Biol., 4, 2009
2FW0
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BU of 2fw0 by Molmil
Apo Open Form of Glucose/Galactose Binding Protein
分子名称: CALCIUM ION, CITRIC ACID, D-galactose-binding periplasmic protein, ...
著者Borrok, M.J, Kiessling, L.L, Forest, K.T.
登録日2006-01-31
公開日2007-02-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.
Protein Sci., 16, 2007
2FVY
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BU of 2fvy by Molmil
High Resolution Glucose Bound Crystal Structure of GGBP
分子名称: ACETATE ION, CALCIUM ION, CARBON DIOXIDE, ...
著者Borrok, M.J, Kiessling, L.L, Forest, K.T.
登録日2006-01-31
公開日2007-02-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (0.92 Å)
主引用文献Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.
Protein Sci., 16, 2007
6YVR
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BU of 6yvr by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13
分子名称: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin crystallisation chaperone, neurotensin NTS8-13 (full agonist), nonyl beta-D-glucopyranoside
著者Deluigi, M, Merklinger, L, Hilge, M, Ernst, P, Klipp, A, Klenk, C, Plueckthun, A.
登録日2020-04-28
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.458 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
3MMJ
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BU of 3mmj by Molmil
Structure of the PTP-like phytase from Selenomonas ruminantium in complex with myo-inositol hexakisphosphate
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Gruninger, R.J, Selinger, L.B, Mosimann, S.C.
登録日2010-04-20
公開日2011-06-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Substrate binding in protein-tyrosine phosphatase-like inositol polyphosphatases.
J.Biol.Chem., 287, 2012
4WMQ
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BU of 4wmq by Molmil
Structure of Human Intelectin-1
分子名称: CALCIUM ION, Intelectin-1
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2014-10-09
公開日2015-07-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Recognition of microbial glycans by human intelectin-1.
Nat.Struct.Mol.Biol., 22, 2015
6Z4Q
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BU of 6z4q by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A
分子名称: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.923 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6ZIN
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BU of 6zin by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692
分子名称: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-06-26
公開日2021-02-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.639 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z8N
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BU of 6z8n by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829
分子名称: (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-06-02
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z4S
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BU of 6z4s by Molmil
Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule inverse agonist SR48692
分子名称: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.707 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z66
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Crystal structure of apo-state neurotensin receptor 1
分子名称: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-27
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.192 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021

 

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