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PDB: 86 件

6XKK
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Cryo-EM structure of the NLRP1-CARD filament
分子名称: NACHT, LRR and PYD domains-containing protein 1
著者Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
登録日2020-06-26
公開日2020-11-25
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6XKJ
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Cryo-EM structure of CARD8-CARD filament
分子名称: Caspase recruitment domain-containing protein 8
著者Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
登録日2020-06-26
公開日2020-11-25
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
7KEU
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Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer
分子名称: Apoptosis-associated speck-like protein containing a CARD, Caspase-1
著者Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H.
登録日2020-10-12
公開日2020-11-25
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6X6C
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Cryo-EM structure of NLRP1-DPP9-VbP complex
分子名称: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ...
著者Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
登録日2020-05-27
公開日2021-03-10
最終更新日2021-05-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6X6A
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Cryo-EM structure of NLRP1-DPP9 complex
分子名称: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1
著者Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
登録日2020-05-27
公開日2021-03-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
4PX9
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DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X
著者Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
登録日2014-03-22
公開日2015-03-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
4PXA
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DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION
著者Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
登録日2014-03-22
公開日2015-03-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
8K8T
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Structure of CUL3-RBX1-KLHL22 complex
分子名称: Cullin-3, Kelch-like protein 22
著者Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y.
登録日2023-07-31
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
8K9I
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Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif
分子名称: Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ...
著者Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y.
登録日2023-08-01
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
7B6W
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Crystal structure of the human alpha1B adrenergic receptor in complex with inverse agonist (+)-cyclazosin
分子名称: Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor, [(4~{a}~{R},8~{a}~{S})-4-(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)-2,3,4~{a},5,6,7,8,8~{a}-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone
著者Deluigi, M, Morstein, L, Hilge, M, Schuster, M, Merklinger, L, Klipp, A, Scott, D.J, Plueckthun, A.
登録日2020-12-08
公開日2022-01-12
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.873 Å)
主引用文献Crystal structure of the alpha 1B -adrenergic receptor reveals molecular determinants of selective ligand recognition.
Nat Commun, 13, 2022
4R7Z
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PfMCM-AAA double-octamer
分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 21, MAGNESIUM ION
著者Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J.
登録日2014-08-28
公開日2014-10-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
4R7Y
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Crystal structure of an active MCM hexamer
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J.
登録日2014-08-28
公開日2014-10-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
2MAI
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NMR structure of lassomycin
分子名称: Lassomycin
著者Gavrish, E, Sit, C.S, Kandror, O, Spoering, A, Peoples, A, Ling, L, Fetterman, A, Hughes, D, Cao, S, Bissell, A, Torrey, H, Akopian, T, Mueller, A, Epstein, S, Goldberg, A, Clardy, J, Lewis, K.
登録日2013-07-09
公開日2014-05-07
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2.
Chem.Biol., 21, 2014
4WMY
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Structure of Human intelectin-1 in complex with allyl-beta-galactofuranose
分子名称: CALCIUM ION, Intelectin-1, prop-2-en-1-yl beta-D-galactofuranoside
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2014-10-09
公開日2015-07-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Recognition of microbial glycans by human intelectin-1.
Nat.Struct.Mol.Biol., 22, 2015
4WMQ
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Structure of Human Intelectin-1
分子名称: CALCIUM ION, Intelectin-1
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2014-10-09
公開日2015-07-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Recognition of microbial glycans by human intelectin-1.
Nat.Struct.Mol.Biol., 22, 2015
4XGK
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Crystal structure of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic
分子名称: DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SULFATE ION, UDP-galactopyranose mutase, ...
著者Wangkanont, K, Heroux, A, Forest, K.T, Kiessling, L.L.
登録日2014-12-31
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.652 Å)
主引用文献Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.
Acs Chem.Biol., 10, 2015
8UV0
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Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
分子名称: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2
著者Deller, M.C, Epling, L.B.
登録日2023-11-02
公開日2024-02-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J.Med.Chem., 67, 2024
4WMO
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Selenomethionine derivative of Xenopus laevis embryonic epidermal lectin carbohydrate-binding domain
分子名称: CALCIUM ION, PENTAETHYLENE GLYCOL, XEEL protein
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2014-10-09
公開日2016-01-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
J.Biol.Chem., 291, 2016
6XTU
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FULL-LENGTH LTTR LYSG FROM CORYNEBACTERIUM GLUTAMICUM
分子名称: Lysine export transcriptional regulatory protein LysG
著者Hofmann, E, Syberg, F, Schlicker, C, Eggeling, L, Schendzielorz, G.
登録日2020-01-16
公開日2020-10-07
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Engineering and application of a biosensor with focused ligand specificity.
Nat Commun, 11, 2020
6XTV
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FULL-LENGTH LTTR LYSG FROM CORYNEBACTERIUM GLUTAMICUM WITH BOUND EFFECTOR ARG
分子名称: ARGININE, Lysine export transcriptional regulatory protein LysG
著者Hofmann, E, Syberg, F, Schlicker, C, Eggeling, L, Schendzielorz, G.
登録日2020-01-16
公開日2020-10-07
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Engineering and application of a biosensor with focused ligand specificity.
Nat Commun, 11, 2020
5D8N
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Tomato leucine aminopeptidase mutant - K354E
分子名称: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
著者DuPrez, K.T, Scranton, M.A, Walling, L.L, Fan, L.
登録日2015-08-17
公開日2016-05-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural insights into chaperone-activity enhancement by a K354E mutation in tomato acidic leucine aminopeptidase.
Acta Crystallogr D Struct Biol, 72, 2016
4WN0
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Xenopus laevis embryonic epidermal lectin in complex with glycerol phosphate
分子名称: CALCIUM ION, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ...
著者Wangkanont, K, Kiessling, L.L, Forest, K.T.
登録日2014-10-10
公開日2016-01-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
J.Biol.Chem., 291, 2016
8E1X
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FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)
分子名称: (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2
著者Lei, H.-T, Epling, L.B, Deller, M.C.
登録日2022-08-11
公開日2022-11-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
J.Med.Chem., 65, 2022
4XAD
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Crystal structure of hen egg white lysozyme in complex with Galf-GlcNAc
分子名称: CHLORIDE ION, Lysozyme C, beta-D-galactofuranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose
著者Wangkanont, K, Kiessling, L.L.
登録日2014-12-14
公開日2014-12-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal structure of hen egg white lysozyme in complex with Galf-GlcNAc, an O-linked disaccharide core from Trypanosoma cruzi
to be published
4XJJ
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Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201
分子名称: 3-[2-(2-hydroxyethyl)pyridinium-1-yl]propane-1-sulfonate, TGF-beta receptor type-2
著者Wangkanont, K, Forest, K.T, Kiessling, L.L.
登録日2015-01-08
公開日2015-06-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201
to be published

 

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