7C29
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![BU of 7c29 by Molmil](/molmil-images/mine/7c29) | Esterase CrmE10 mutant-D178A | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Li, Z, Li, J. | Deposit date: | 2020-05-07 | Release date: | 2020-05-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels, 13, 2020
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8DSV
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![BU of 8dsv by Molmil](/molmil-images/mine/8dsv) | The structure of NicA2 in complex with N-methylmyosmine | Descriptor: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, FAD-dependent oxidoreductase, ... | Authors: | Wu, K, Dulchavsky, M, Li, J, Bardwell, J.C.A. | Deposit date: | 2022-07-22 | Release date: | 2023-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme. Nat.Chem.Biol., 19, 2023
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8DQ7
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8DQ8
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![BU of 8dq8 by Molmil](/molmil-images/mine/8dq8) | The structure of NicA2 variant F104L/A107T/S146I/G317D/H368R/L449V/N462S in complex with N-methylmyosmine | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 1,2-ETHANEDIOL, Amine oxidase, ... | Authors: | Wu, K, Dulchavsky, M, Li, J, Bardwell, J.C.A. | Deposit date: | 2022-07-18 | Release date: | 2023-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme. Nat.Chem.Biol., 19, 2023
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7YFU
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![BU of 7yfu by Molmil](/molmil-images/mine/7yfu) | Structure of Rpgrip1l CC2 | Descriptor: | Protein fantom | Authors: | He, R, Chen, G, Li, Z, Li, J. | Deposit date: | 2022-07-09 | Release date: | 2023-05-17 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the N-terminal coiled-coil domains of the ciliary protein Rpgrip1l. Iscience, 26, 2023
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7YFV
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![BU of 7yfv by Molmil](/molmil-images/mine/7yfv) | Structure of Rpgrip1l CC1 | Descriptor: | Protein fantom | Authors: | He, R, Chen, G, Li, Z, Li, J. | Deposit date: | 2022-07-09 | Release date: | 2023-05-17 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the N-terminal coiled-coil domains of the ciliary protein Rpgrip1l. Iscience, 26, 2023
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6L0O
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![BU of 6l0o by Molmil](/molmil-images/mine/6l0o) | WH domain of human MCM8 | Descriptor: | DNA helicase MCM8, SULFATE ION | Authors: | Liu, Y, Li, J, Liu, L, Zeng, H. | Deposit date: | 2019-09-26 | Release date: | 2020-04-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Crystal structure of the winged-helix domain of MCM8. Biochem.Biophys.Res.Commun., 526, 2020
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7XRY
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![BU of 7xry by Molmil](/molmil-images/mine/7xry) | Crystal structure of MERS main protease in complex with inhibitor YH-53 | Descriptor: | N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, ORF1a | Authors: | Lin, C, Zhong, F.L, Zhou, X.L, Li, J, Zhang, J. | Deposit date: | 2022-05-12 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14, 2022
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7XRS
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![BU of 7xrs by Molmil](/molmil-images/mine/7xrs) | Crystal structure of SARS-Cov-2 main protease in complex with inhibitor YH-53 | Descriptor: | N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1a | Authors: | Zhou, X.L, Zhong, F.L, Lin, C, Zeng, P, Zhang, J, Li, J. | Deposit date: | 2022-05-11 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14, 2022
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7YGQ
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![BU of 7ygq by Molmil](/molmil-images/mine/7ygq) | Crystal structure of SARS main protease in complex with inhibitor YH-53 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Lin, C, Zhong, F.L, Zhou, X.L, Zeng, P, Zhang, J, Li, J. | Deposit date: | 2022-07-12 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14, 2022
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6K9L
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![BU of 6k9l by Molmil](/molmil-images/mine/6k9l) | 4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase | Descriptor: | Serine-protein kinase ATM | Authors: | Xiao, J, Liu, M, Qi, Y, Chaban, Y, Gao, C, Tian, Y, Yu, Z, Li, J, Zhang, P, Xu, Y. | Deposit date: | 2019-06-16 | Release date: | 2019-12-25 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structural insights into the activation of ATM kinase. Cell Res., 29, 2019
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4LRH
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![BU of 4lrh by Molmil](/molmil-images/mine/4lrh) | Crystal structure of human folate receptor alpha in complex with folic acid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, Folate receptor alpha | Authors: | Ke, J, Chen, C, Zhou, X.E, Yi, W, Brunzelle, J.S, Li, J, Young, E.-L, Xu, H.E, Melcher, K. | Deposit date: | 2013-07-19 | Release date: | 2013-07-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for molecular recognition of folic acid by folate receptors. Nature, 500, 2013
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7YRZ
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![BU of 7yrz by Molmil](/molmil-images/mine/7yrz) | Crystal structure of HCoV 229E main protease in complex with PF07321332 | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase | Authors: | Zhou, Y.R, Zeng, P, Zhou, X.L, Lin, C, Zhang, J, Yin, X.S, Li, J. | Deposit date: | 2022-08-11 | Release date: | 2023-08-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332. Biochem.Biophys.Res.Commun., 657, 2023
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7Y0A
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7Y0B
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![BU of 7y0b by Molmil](/molmil-images/mine/7y0b) | Crystal structure of human short-chain acyl-CoA dehydrogenase | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, FLAVIN-ADENINE DINUCLEOTIDE, Short-chain specific acyl-CoA dehydrogenase, ... | Authors: | Huang, Y, Xu, Y, Li, J. | Deposit date: | 2022-06-04 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.076 Å) | Cite: | Crystal structure of human short-chain acyl-coA dehydrogenase To Be Published
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4ARY
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![BU of 4ary by Molmil](/molmil-images/mine/4ary) | Lepidopteran-specific toxin Cry1Ac in complex with receptor specificity determinant GalNAc | Descriptor: | 1,3-DIAMINOPROPANE, 2-acetamido-2-deoxy-beta-D-galactopyranose, PESTICIDAL CRYSTAL PROTEIN CRY1AC | Authors: | Derbyshire, D.J, Carroll, J, Ellar, D.J, Li, J. | Deposit date: | 2012-04-27 | Release date: | 2013-05-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural Basis of Galnac-Dependent Receptor Recognition by B. Thuringiensis Toxin Cry1Ac To be Published
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7P8W
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![BU of 7p8w by Molmil](/molmil-images/mine/7p8w) | Human erythrocyte catalase cryoEM | Descriptor: | Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chen, S, Li, J, Vinothkumar, K.R, Henderson, R. | Deposit date: | 2021-07-23 | Release date: | 2021-08-25 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Interaction of human erythrocyte catalase with air-water interface in cryoEM. Microscopy (Oxf), 71, 2022
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6LAR
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![BU of 6lar by Molmil](/molmil-images/mine/6lar) | Structure of ESX-3 complex | Descriptor: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | Authors: | Wang, S.H, Zhou, K.X, Li, J, Rao, Z.H. | Deposit date: | 2019-11-13 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | cryo-em structure of esx-3 To Be Published
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5JI8
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![BU of 5ji8 by Molmil](/molmil-images/mine/5ji8) | Crystal structure of the BRD9 bromodomain and hit 1 | Descriptor: | 2-amino-1,3-benzothiazole-6-carboxamide, Bromodomain-containing protein 9 | Authors: | Wang, N, Li, F, Bao, H, Li, J, Wu, J, Ruan, K. | Deposit date: | 2016-04-22 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains Chembiochem, 17, 2016
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7YF7
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![BU of 7yf7 by Molmil](/molmil-images/mine/7yf7) | |
6JZO
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![BU of 6jzo by Molmil](/molmil-images/mine/6jzo) | Structure of the mouse TRPC4 ion channel | Descriptor: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | Authors: | Duan, J, Li, Z, Li, J, Zhang, J. | Deposit date: | 2019-05-03 | Release date: | 2020-10-21 | Last modified: | 2021-05-05 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Structure of the mouse TRPC4 ion channel To Be Published
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7MHR
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![BU of 7mhr by Molmil](/molmil-images/mine/7mhr) | KcsA E71V closed gate with K+ | Descriptor: | Fab heavy chain, Fab light chain, POTASSIUM ION, ... | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | Deposit date: | 2021-04-15 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V. Nat Commun, 13, 2022
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7MHX
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![BU of 7mhx by Molmil](/molmil-images/mine/7mhx) | KcsA E71V closed gate with Ba2+ | Descriptor: | BARIUM ION, DIACYL GLYCEROL, Fab heavy chain, ... | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | Deposit date: | 2021-04-15 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V. Nat Commun, 13, 2022
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7MUB
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![BU of 7mub by Molmil](/molmil-images/mine/7mub) | KcsA Open gate E71V mutant in Potassium | Descriptor: | Fab heavy chain, Fab light chain, POTASSIUM ION, ... | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | Deposit date: | 2021-05-14 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V. Nat Commun, 13, 2022
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7MJT
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![BU of 7mjt by Molmil](/molmil-images/mine/7mjt) | KcsA open gate E71V mutant with Barium | Descriptor: | BARIUM ION, Fab heavy chain, Fab light chain, ... | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | Deposit date: | 2021-04-20 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V. Nat Commun, 13, 2022
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