7YRZ

Crystal structure of HCoV 229E main protease in complex with PF07321332

Summary for 7YRZ

• Entry DOI: 10.2210/pdb7yrz/pdb
• Descriptor: 3C-like proteinase, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• Functional Keywords: viral protein
• Biological source: Human coronavirus 229E
• Total number of polymer chains: 2
• Total formula weight: 67170.24

Authors

Zhou, Y.R.,Zeng, P.,Zhou, X.L.,Lin, C.,Zhang, J.,Yin, X.S.,Li, J. (deposition date: 2022-08-11, release date: 2023-08-16, Last modification date: 2024-03-06)

• Primary citation: Zhou, Y.,Wang, W.,Zeng, P.,Feng, J.,Li, D.,Jing, Y.,Zhang, J.,Yin, X.,Li, J.,Ye, H.,Wang, Q.; Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332.; Biochem.Biophys.Res.Commun., 657:16-23, 2023; PubMed: 36965419; DOI: 10.1016/j.bbrc.2023.03.043

Experimental method

X-RAY DIFFRACTION (1.79 Å)