7YAV
 
 | | Crystal structure of Diels-Alderase MaDA1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, MaDA1 | | 著者 | Lei, X.G, Chen, R.C, Du, X.X, Yang, J, Fan, J.P, Guo, N.X, Ding, Q. | | 登録日 | 2022-06-28 | | 公開日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of Diels-Alderase MaDA1
To Be Published
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6WC2
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6BZ1
 | | MEF2 Chimera D83V mutant/DNA complex | | 分子名称: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), MEF2 CHIMERA | | 著者 | Lei, X, Chen, L. | | 登録日 | 2017-12-21 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
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6C9L
 | | MEF2B Apo Protein Structure | | 分子名称: | Myocyte-specific enhancer factor 2B | | 著者 | Lei, X, Chen, L. | | 登録日 | 2018-01-26 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Apo MEF2B Reveals New Insights in DNA Binding and Cofactor Interaction.
Biochemistry, 57, 2018
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6BYY
 | | MEF2 CHIMERA/DNA Complex | | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), ... | | 著者 | Lei, X, Chen, L. | | 登録日 | 2017-12-21 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
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8JU6
 | | Structure of human TRPV4 with antagonist GSK279 | | 分子名称: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-24 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JU5
 | | Structure of human TRPV4 with antagonist A1 | | 分子名称: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-24 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVJ
 | | Structure of human TRPV4 with antagonist A2 and RhoA | | 分子名称: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVI
 | | Structure of human TRPV4 with antagonist A2 | | 分子名称: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8K2P
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8K2O
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8JQR
 | | Structure of human TRPV1 in complex with antagonist | | 分子名称: | 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile, CHOLESTEROL, Transient receptor potential cation channel subfamily V member 1,PreScission Site,Green fluorescent protein | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-14 | | 公開日 | 2024-08-14 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Structural basis of TRPV1 inhibition by SAF312 and cholesterol.
Nat Commun, 15, 2024
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8X94
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1QWO
 | | Crystal structure of a phosphorylated phytase from Aspergillus fumigatus, revealing the structural basis for its heat resilience and catalytic pathway | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, phytase | | 著者 | Xiang, T, Liu, Q, Deacon, A.M, Koshy, M, Kriksunov, I.A, Lei, X.G, Hao, Q, Thiel, D.J. | | 登録日 | 2003-09-03 | | 公開日 | 2004-06-01 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal Structure of a Heat-resilient Phytase from Aspergillus fumigatus, Carrying a Phosphorylated Histidine
J.Mol.Biol., 339, 2004
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8VY8
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6WC5
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1SK8
 | | Crystallographic snapshots of Aspergillus fumigatus phytase revealing its enzymatic dynamics | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-phytase A, PHOSPHATE ION | | 著者 | Liu, Q, Huang, Q.Q, Lei, X.G, Hao, Q. | | 登録日 | 2004-03-04 | | 公開日 | 2005-02-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystallographic Snapshots of Aspergillus fumigatus Phytase, Revealing Its Enzymatic Dynamics
Structure, 12, 2004
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1SKB
 | | Crystallographic snapshots of Aspergillus fumigatus phytase revealing its enzymatic dynamics | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-phytase A | | 著者 | Liu, Q, Huang, Q, Lei, X.G, Hao, Q. | | 登録日 | 2004-03-04 | | 公開日 | 2004-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Crystallographic Snapshots of Aspergillus fumigatus Phytase, Revealing Its Enzymatic Dynamics
Structure, 12, 2004
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1SK9
 | | Crystallographic snapshots of Aspergillus fumigatus phytase revealing its enzymatic dynamics | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-phytase A, PHOSPHATE ION | | 著者 | Liu, Q, Huang, Q, Lei, X.G, Hao, Q. | | 登録日 | 2004-03-04 | | 公開日 | 2004-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Crystallographic Snapshots of Aspergillus fumigatus Phytase, Revealing Its Enzymatic Dynamics
Structure, 12, 2004
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1SKA
 | | Crystallographic snapshots of Aspergillus fumigatus phytase revealing its enzymatic dynamics | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-phytase A | | 著者 | Liu, Q, Huang, Q, Lei, X.G, Hao, Q. | | 登録日 | 2004-03-04 | | 公開日 | 2004-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Crystallographic Snapshots of Aspergillus fumigatus Phytase, Revealing Its Enzymatic Dynamics
Structure, 12, 2004
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3QZR
 | | Human enterovirus 71 3C protease mutant E71A in complex with rupintrivir | | 分子名称: | 1,2-ETHANEDIOL, 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | | 著者 | Wang, J, Fan, T, Yao, X, Wu, Z, Guo, L, Lei, X, Wang, J, Wang, M, Jin, Q, Cui, S. | | 登録日 | 2011-03-07 | | 公開日 | 2011-08-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.039 Å) | | 主引用文献 | Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
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3QZQ
 | | Human enterovirus 71 3C protease mutant E71D in complex with rupintrivir | | 分子名称: | 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | | 著者 | Wang, J, Fan, T, Yao, X, Wu, Z, Guo, L, Lei, X, Wang, J, Wang, M, Jin, Q, Cui, S. | | 登録日 | 2011-03-07 | | 公開日 | 2011-08-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7001 Å) | | 主引用文献 | Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
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3R0F
 | | Human enterovirus 71 3C protease mutant H133G in complex with rupintrivir | | 分子名称: | 1,2-ETHANEDIOL, 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | | 著者 | Wang, J, Fan, T, Yao, X, Wu, Z, Guo, L, Lei, X, Wang, J, Wang, M, Jin, Q, Cui, S. | | 登録日 | 2011-03-08 | | 公開日 | 2011-08-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.3083 Å) | | 主引用文献 | Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
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6JQH
 | | Crystal structure of MaDA | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MaDA | | 著者 | Du, X.X, Lei, X.G. | | 登録日 | 2019-03-31 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | | 主引用文献 | FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis.
Nat.Chem., 12, 2020
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7YOC
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