6T8V
 
 | | Complement factor B in complex with (S)-5,7-Dimethyl-4-((2-phenylpiperidin-1-yl)methyl)-1H-indole | | 分子名称: | 4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ... | | 著者 | Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Mac Sweeney, A, Wiesmann, C, Adams, C, Mainolfi, N, Liao, S.-M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Serrano-Wu, M, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, De Erkenez, A, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Wiesmann, C, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M. | | 登録日 | 2019-10-25 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
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6O6W
 | | Solution structure of human myeloid-derived growth factor | | 分子名称: | Myeloid-derived growth factor | | 著者 | Bortnov, V, Tonelli, M, Lee, W, Markley, J.L, Mosher, D.F. | | 登録日 | 2019-03-07 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum.
Nat Commun, 10, 2019
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1CQ0
 | | SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B'SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B ' | | 分子名称: | PROTEIN (NEW HYPOTHALAMIC NEUROPEPTIDE/OREXIN-B28) | | 著者 | Lee, K.-H, Bang, E.J, Chae, K.-J, Lee, D.W, Lee, W. | | 登録日 | 1999-08-04 | | 公開日 | 2000-01-10 | | 最終更新日 | 2024-04-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B.
Eur.J.Biochem., 266, 1999
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1HVB
 | | CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN | | 分子名称: | 5-{3-(S)-(4-(R)-ACETYLAMINO-4-CARBOXY-BUTYRYLAMINO)-3-[1-(R)-(1-(R)-CARBOXY-ETHYLCARBAMOYL)-ETHYLCARBAMOYL]-PROPYL}-2-( CARBOXY-PHENYLACETYLAMINO-METHYL)-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE | | 著者 | McDonough, M.A, Lee, W, Silvaggi, N.R, Mobashery, S, Kelly, J.A. | | 登録日 | 2001-01-08 | | 公開日 | 2001-02-07 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1RYJ
 | | Solution NMR Structure of Protein Mth1743 from Methanobacterium thermoautotrophicum. Ontario Centre for Structural Proteomics target MTH1743_1_70; Northeast Structural Genomics Consortium Target TT526. | | 分子名称: | unknown | | 著者 | Yee, A, Chang, X, Pineda-Lucena, A, Wu, B, Semesi, A, Le, B, Ramelot, T, Lee, G.M, Bhattacharyya, S, Gutierrez, P, Denisov, A, Lee, C.H, Cort, J.R, Kozlov, G, Liao, J, Finak, G, Chen, L, Wishart, D, Lee, W, McIntosh, L.P, Gehring, K, Kennedy, M.A, Edwards, A.M, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2003-12-22 | | 公開日 | 2004-02-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | AN NMR APPROACH TO STRUCTURAL PROTEOMICS
Proc.Natl.Acad.Sci.USA, 99, 2002
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1RJA
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4ZG0
 | | Crystal structure of Mouse Syndesmos protein | | 分子名称: | Protein syndesmos | | 著者 | Lee, I, Kim, H, Yoo, J, Cho, H, Lee, W. | | 登録日 | 2015-04-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | | 主引用文献 | Crystal structure of syndesmos and its interaction with Syndecan-4 proteoglycan
Biochem.Biophys.Res.Commun., 463, 2015
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6CGH
 | | Solution structure of the four-helix bundle region of human J-protein Zuotin, a component of ribosome-associated complex (RAC) | | 分子名称: | DnaJ homolog subfamily C member 2 | | 著者 | Shrestha, O.K, Lee, W, Tonelli, M, Cornilescu, G, Markley, J.L, Ciesielski, S.J, Craig, E.A. | | 登録日 | 2018-02-20 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70.
Plos One, 14, 2019
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6WQE
 | | Solution Structure of the IWP-051-bound H-NOX from Shewanella woodyi in the Fe(II)CO ligation state | | 分子名称: | 5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-ol, CARBON MONOXIDE, Heme NO binding domain protein, ... | | 著者 | Chen, C.Y, Lee, W, Montfort, W.R. | | 登録日 | 2020-04-28 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the Shewanella woodyi H-NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP-051.
Protein Sci., 30, 2021
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1IQO
 | | Solution structure of MTH1880 from methanobacterium thermoautotrophicum | | 分子名称: | HYPOTHETICAL PROTEIN MTH1880 | | 著者 | Lee, C.H, Shin, J, Bang, E, Jung, J.W, Yee, A, Arrowsmith, C.H, Lee, W. | | 登録日 | 2001-07-23 | | 公開日 | 2002-07-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.
Protein Sci., 13, 2004
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1IQS
 | | Minimized average structure of MTH1880 from Methanobacterium Thermoautotrophicum | | 分子名称: | MTH1880 | | 著者 | Lee, C.H, Shin, J, Bang, E, Jung, J.W, Yee, A, Arrowsmith, C.H, Lee, W. | | 登録日 | 2001-07-29 | | 公開日 | 2002-07-29 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.
Protein Sci., 13, 2004
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1FUW
 | | SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A DOUBLE MUTANT SINGLE-CHAIN MONELLIN(SCM) DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | | 分子名称: | MONELLIN | | 著者 | Sung, Y.H, Shin, J, Jung, J, Lee, W. | | 登録日 | 2000-09-18 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure, backbone dynamics, and stability of a double mutant single-chain monellin. structural origin of sweetness.
J.Biol.Chem., 276, 2001
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3K9P
 | | The crystal structure of E2-25K and ubiquitin complex | | 分子名称: | Ubiquitin, Ubiquitin-conjugating enzyme E2 K | | 著者 | Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. | | 登録日 | 2009-10-16 | | 公開日 | 2010-09-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
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8HNJ
 | | Domain-stabilized glutamine-binding protein | | 分子名称: | GLUTAMINE, Glutamine ABC transporter, periplasmic glutamine-binding protein GlnH | | 著者 | Choi, S.H, Park, J.H, Seo, M.H, Park, K.W, Lee, W.K. | | 登録日 | 2022-12-08 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Domain-wise dissection of thermal stability enhancement in multidomain proteins.
Int.J.Biol.Macromol., 237, 2023
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6OCV
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2NLU
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6LVU
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7LHQ
 | | Solution structure of SARS-CoV-2 nonstructural protein 7 at pH 7.0 | | 分子名称: | Non-structural protein 7 | | 著者 | Lee, Y, Tonelli, M, Anderson, T.K, Kirchdoerfer, R.N, Henzler-Wildman, K, Lee, W. | | 登録日 | 2021-01-26 | | 公開日 | 2022-02-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | pH-dependent polymorphism of the structure of SARS-CoV-2 nsp7
Biorxiv, 2021
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6DTX
 | | Wildtype HIV-1 Reverse Transcriptase in complex with JLJ 578 | | 分子名称: | 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, GLYCEROL, Reverse transcriptase/ribonuclease H, ... | | 著者 | Sasaki, T, Gannam, Z.T.K, Anderson, K.S, Jorgensen, W.L, Lee, W. | | 登録日 | 2018-06-18 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.327 Å) | | 主引用文献 | Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 29, 2019
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6DTW
 | | HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578 | | 分子名称: | 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | | 著者 | Sasaki, T, Gannam, Z.T.K, Anderson, K.S, Jorgensen, W.L, Lee, W. | | 登録日 | 2018-06-18 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.742 Å) | | 主引用文献 | Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 29, 2019
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2KCC
 | | Solution Structure of biotinoyl domain from human acetyl-CoA carboxylase 2 | | 分子名称: | Acetyl-CoA carboxylase 2 | | 著者 | Lee, C, Cheong, H, Ryu, K, Lee, J, Lee, W, Jeon, Y, Cheong, C. | | 登録日 | 2008-12-19 | | 公開日 | 2009-02-17 | | 最終更新日 | 2023-09-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Biotinoyl domain of human acetyl-CoA carboxylase: Structural insights into the carboxyl transfer mechanism.
Proteins, 72, 2008
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5G1D
 | | The complex structure of syntenin-1 PDZ domain with c-terminal extension | | 分子名称: | SYNDECAN-4, SYNTENIN-1 | | 著者 | Lee, I, Kim, H, Yun, J.H, Lee, W. | | 登録日 | 2016-03-25 | | 公開日 | 2016-11-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | New Structural Insight of C-Terminal Region of Syntenin-1, Enhancing the Molecular Dimerization and Inhibitory Function Related on Syndecan-4 Signaling.
Sci.Rep., 6, 2016
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5G1E
 | | The complex structure of syntenin-1 PDZ domain with c-terminal extension | | 分子名称: | SYNTENIN-1 | | 著者 | Lee, I, Kim, H, Yun, J.H, Lee, W. | | 登録日 | 2016-03-25 | | 公開日 | 2016-11-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | New Structural Insight of C-Terminal Region of Syntenin-1, Enhancing the Molecular Dimerization and Inhibitory Function Related on Syndecan-4 Signaling.
Sci.Rep., 6, 2016
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3TD5
 | | Crystal structure of OmpA-like domain from Acinetobacter baumannii in complex with L-Ala-gamma-D-Glu-m-DAP-D-Ala-D-Ala | | 分子名称: | CHLORIDE ION, Outer membrane protein omp38, peptide(L-Ala-gamma-D-Glu-m-DAP-D-Ala-D-Ala) | | 著者 | Park, J.S, Lee, W.C, Song, J.H, Kim, H.Y. | | 登録日 | 2011-08-10 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane
Faseb J., 26, 2012
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3TD4
 | | Crystal structure of OmpA-like domain from Acinetobacter baumannii in complex with diaminopimelate | | 分子名称: | 2,6-DIAMINOPIMELIC ACID, Outer membrane protein omp38 | | 著者 | Park, J.S, Lee, W.C, Song, J.H, Kim, H.Y. | | 登録日 | 2011-08-10 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane
Faseb J., 26, 2012
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