Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor

Summary for 2NLU

Related1RI0 2B8A 1N27
DescriptorHepatoma-derived growth factor (1 entity in total)
Functional Keywordshdgf, hhdgf, hrp, hath, pwwp, heparin, domain-swapping, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P51858
Total number of polymer chains2
Total molecular weight23128.24
Sue, S.C.,Lee, W.T.,Huang, T.H. (deposition date: 2006-10-20, release date: 2007-09-04, Last modification date: 2011-07-13)
Primary citation
Sue, S.C.,Lee, W.T.,Tien, S.C.,Lee, S.C.,Yu, J.G.,Wu, W.J.,Wu, W.G.,Huang, T.H.
PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin
J.Mol.Biol., 367:456-472, 2007
PubMed: 17270212 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2007.01.010
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers10 1.4% 7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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PDB entries from 2020-11-25