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PDB: 51 件
3DZI
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Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex
分子名称: 2-amino-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-9H-purin-6-yl 5-O-phosphono-beta-D-ribofuranoside, ADP-ribosyl cyclase 1, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, ...
著者Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
登録日2008-07-29
公開日2008-11-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZH
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Crystal structure of human CD38 extracellular domain, GTP complex
分子名称: ADP-ribosyl cyclase 1, GUANOSINE-5'-TRIPHOSPHATE
著者Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
登録日2008-07-29
公開日2008-11-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZK
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Crystal structure of human CD38 extracellular domain, NMN complex
分子名称: ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
著者Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
登録日2008-07-29
公開日2008-11-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3F6Y
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Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium
分子名称: ADP-ribosyl cyclase 1, CALCIUM ION
著者Liu, Q, Graeff, R, Kriksunov, I.A, Lam, C.M.C, Lee, H.C, Hao, Q.
登録日2008-11-07
公開日2008-11-18
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium
Biochemistry, 47, 2008
3DZG
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Crystal structure of human CD38 extracellular domain, ara-F-ribose-5'-phosphate/nicotinamide complex
分子名称: 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose, ADP-ribosyl cyclase 1, NICOTINAMIDE
著者Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
登録日2008-07-29
公開日2008-11-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZJ
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Crystal structure of human CD38 extracellular domain E226Q mutant, NMN complex
分子名称: ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
著者Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
登録日2008-07-29
公開日2008-11-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3ROP
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Crystal structure of human CD38 in complex with compound CZ-50b
分子名称: 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-ribofuranose, ADP-ribosyl cyclase 1, NICOTINAMIDE
著者Zhang, H, Lee, H.C, Hao, Q.
登録日2011-04-26
公開日2011-12-28
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3RAJ
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Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7
分子名称: ADP-ribosyl cyclase 1, heavy chain of the Fab fragment of antibody HB7, light chain of the Fab fragment of antibody HB7
著者Zhang, H, Lee, H.C, Hao, Q.
登録日2011-03-28
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.044 Å)
主引用文献Engineering a novel cytosolic form of CD38 for cyclic ADP-ribose dependent signaling
To be Published
3ROK
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Crystal structure of human CD38 in complex with compound CZ-27
分子名称: 5-O-[(S)-butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-alpha-D-arabinofuranose, ADP-ribosyl cyclase 1
著者Zhang, H, Lee, H.C, Hao, Q.
登録日2011-04-26
公開日2011-12-21
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROQ
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Crystal structure of human CD38 in complex with compound CZ-46
分子名称: (2R,3R,4S,5S)-4-fluoro-3,5-dihydroxytetrahydrofuran-2-yl 2-phenylethyl hydrogen (S)-phosphate, ADP-ribosyl cyclase 1
著者Zhang, H, Lee, H.C, Hao, Q.
登録日2011-04-26
公開日2011-12-21
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROM
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Crystal structure of human CD38 in complex with compound CZ-48
分子名称: 2-deoxy-2-fluoro-5-O-thiophosphono-alpha-D-arabinofuranose, ADP-ribosyl cyclase 1
著者Zhang, H, Lee, H.C, Hao, Q.
登録日2011-04-26
公開日2011-12-21
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3OFS
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Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography
分子名称: ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Zhang, H, Lee, H.C, Hao, Q.
登録日2010-08-16
公開日2010-12-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal
J.Mol.Biol., 405, 2011
2HCT
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Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
分子名称: ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
著者Liu, Q, Kriksunov, I.A, Hao, Q, Graeff, R, Lee, H.C.
登録日2006-06-18
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
J.Biol.Chem., 281, 2006
2I66
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Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
分子名称: ADP-ribosyl cyclase 1, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5S)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
登録日2006-08-28
公開日2006-09-05
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I65
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Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
分子名称: ADP-ribosyl cyclase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
登録日2006-08-28
公開日2006-09-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I67
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Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase 1
著者Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
登録日2006-08-28
公開日2006-09-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2O3U
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Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
分子名称: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-ribosyl cyclase 1
著者Liu, Q, Kriksunov, I.A, Graeff, R, Lee, H.C, Hao, Q.
登録日2006-12-01
公開日2006-12-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3S
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Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
分子名称: ADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Lee, H.C, Hao, Q.
登録日2006-12-01
公開日2006-12-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3T
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Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
分子名称: ADP-ribosyl cyclase 1, CYCLIC GUANOSINE DIPHOSPHATE-RIBOSE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Lee, H.C, Hao, Q.
登録日2006-12-01
公開日2006-12-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3Q
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Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
分子名称: ADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Lee, H.C, Hao, Q.
登録日2006-12-01
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3R
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Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
分子名称: ADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Lee, H.C, Hao, Q.
登録日2006-12-01
公開日2006-12-12
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2PGL
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Catalysis associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog
分子名称: ADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
著者Liu, Q, Kriksunov, I.A, Moreau, C, Graeff, R, Potter, B.V.L, Lee, H.C, Hao, Q.
登録日2007-04-09
公開日2007-04-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog
J.Biol.Chem., 282, 2007
2PGJ
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Catalysis associated conformational changes revealed by human cd38 complexed with a non-hydrolyzable substrate analog
分子名称: ADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
著者Liu, Q, Kriksunov, I.A, Moreau, C, Graeff, R, Potter, B.V.L, Lee, H.C, Hao, Q.
登録日2007-04-09
公開日2007-04-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog
J.Biol.Chem., 282, 2007
3U4H
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CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
分子名称: 8-Amino-N1-Cyclic Inosine 5'-Diphosphoribose, ADP-ribosyl cyclase 1
著者Liu, Q, Hao, Q, Lee, H.C, Graeff, R.
登録日2011-10-08
公開日2012-10-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.878 Å)
主引用文献CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
3U4I
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CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
分子名称: ADP-ribosyl cyclase 1, Cyclic adenosine 5'-diphosphocarbocyclic ribose
著者Liu, Q, Hao, Q, Lee, H.C, Graeff, R.
登録日2011-10-08
公開日2012-10-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.118 Å)
主引用文献CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013

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