3U4I
CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
Summary for 3U4I
Entry DOI | 10.2210/pdb3u4i/pdb |
Related | 3U4H |
Descriptor | ADP-ribosyl cyclase 1, Cyclic adenosine 5'-diphosphocarbocyclic ribose (3 entities in total) |
Functional Keywords | non-hydrolyzable inhibitor, two domains, cadpr cyclization, hydrolysis, cadpcr, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type II membrane protein: P28907 |
Total number of polymer chains | 2 |
Total formula weight | 61300.11 |
Authors | Liu, Q.,Hao, Q.,Lee, H.C.,Graeff, R. (deposition date: 2011-10-08, release date: 2012-10-10, Last modification date: 2023-11-01) |
Primary citation | Moreau, C.,Liu, Q.,Graeff, R.,Wagner, G.K.,Thomas, M.P.,Swarbrick, J.M.,Shuto, S.,Lee, H.C.,Hao, Q.,Potter, B.V.L. CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template Plos One, 8:e66247-e66247, 2013 Cited by PubMed: 23840430DOI: 10.1371/journal.pone.0066247 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.118 Å) |
Structure validation
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