2HCT

Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities

Summary for 2HCT

DescriptorADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE (3 entities in total)
Functional Keywordsbeta sheets, alpha bundle, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type II membrane protein P28907
Total number of polymer chains2
Total molecular weight61287.11
Authors
Liu, Q.,Kriksunov, I.A.,Hao, Q.,Graeff, R.,Lee, H.C. (deposition date: 2006-06-18, release date: 2006-08-22, Last modification date: 2011-07-13)
Primary citation
Graeff, R.,Liu, Q.,Kriksunov, I.A.,Hao, Q.,Lee, H.C.
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
J.Biol.Chem., 281:28951-28957, 2006
PubMed: 16861223 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M604370200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.248112.4%5.6%23.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2hct
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Molmil generated image of 2hct
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Molmil generated image of 2hct
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More Biological unit images

Molmil generated image of 2hct
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Molmil generated image of 2hct
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Molmil generated image of 2hct
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2hct.pdb1.gz [45.07 KB])
Coordinate files for Biological unit (2hct.pdb2.gz [45.04 KB])