2HCT
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ADP-ribosyl cyclase 1 | polymer | 262 | 30308.3 | 2 | UniProt (P28907) Pfam (PF02267) | Homo sapiens (human) | Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, Lymphocyte differentiation antigen CD38, T10, Acute lymphoblastic leukemia cells antigen CD38 |
| 2 | C, D (A, B) | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE | non-polymer | 335.2 | 2 | Chemie (NMN) PubChem (939) PubChem (177675032) PubChem (44269211) PubChem (46874984) PubChem (71750998) PubChem (89516131) PubChem (14181) PubChem (90476335) PubChem (6093202) PubChem (93605785) PubChem (9819044) PubChem (122587981) PubChem (123929622) PubChem (124350426) PubChem (15737496) PubChem (134694109) PubChem (147327152) PubChem (149999359) PubChem (164745794) PubChem (167012155) PubChem (172887170) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 300 (UniProt: P28907)
| PDB | External Database | Details |
|---|---|---|
| Lys 39 | - | cloning artifact |
| Arg 40 | - | cloning artifact |
| Glu 41 | - | cloning artifact |
| Ala 42 | - | cloning artifact |
| Glu 43 | - | cloning artifact |
| Ala 44 | - | cloning artifact |
| Thr 49 | - | engineered mutation |
| Asp 100 | Asn 100 | engineered mutation |
| Asp 164 | Asn 164 | engineered mutation |
| Asp 209 | Asn 209 | engineered mutation |
| Asp 219 | Asn 219 | engineered mutation |
| Gly 226 | Glu 226 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60616.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 670.5 | |
| All* | Total formula weight | 61287.1 |
