2HCT
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ADP-ribosyl cyclase 1 | polymer | 262 | 30308.3 | 2 | UniProt (P28907) Pfam (PF02267) In PDB | Homo sapiens (human) | Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, Lymphocyte differentiation antigen CD38, T10, Acute lymphoblastic leukemia cells antigen CD38 |
2 | A, B | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE | non-polymer | 335.2 | 2 | Chemie (NMN) | |||
3 | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 300 (UniProt: P28907)
PDB | External Database | Details |
---|---|---|
Lys 39 | - | cloning artifact |
Arg 40 | - | cloning artifact |
Glu 41 | - | cloning artifact |
Ala 42 | - | cloning artifact |
Glu 43 | - | cloning artifact |
Ala 44 | - | cloning artifact |
Thr 49 | - | engineered mutation |
Asp 100 | Asn 100 | engineered mutation |
Asp 164 | Asn 164 | engineered mutation |
Asp 209 | Asn 209 | engineered mutation |
Asp 219 | Asn 219 | engineered mutation |
Gly 226 | Glu 226 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 60616.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 670.5 | |
All* | Total formula weight | 61287.1 |