2HCT
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NMN A 301 |
| Chain | Residue |
| A | TRP125 |
| A | SER220 |
| A | THR221 |
| A | PHE222 |
| A | HOH404 |
| A | SER126 |
| A | ARG127 |
| A | LEU145 |
| A | GLU146 |
| A | ASP155 |
| A | ASP156 |
| A | TRP189 |
| A | SER193 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NMN B 302 |
| Chain | Residue |
| B | TRP125 |
| B | SER126 |
| B | ARG127 |
| B | LYS129 |
| B | LEU145 |
| B | GLU146 |
| B | ASP155 |
| B | ASP156 |
| B | TRP189 |
| B | SER193 |
| B | SER220 |
| B | THR221 |
| B | PHE222 |
| B | HOH415 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"7961800","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
