3F6Y

Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium

Summary for 3F6Y

Entry DOI	10.2210/pdb3f6y/pdb
Descriptor	ADP-ribosyl cyclase 1, CALCIUM ION (3 entities in total)
Functional Keywords	calcium loaded structure, active site closure, inhibitory conformation, alternative splicing, diabetes mellitus, glycoprotein, hydrolase, membrane, nad, polymorphism, receptor, signal-anchor, transmembrane
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type II membrane protein: P28907
Total number of polymer chains	1
Total formula weight	30490.61
Authors	Liu, Q.,Graeff, R.,Kriksunov, I.A.,Lam, C.M.C.,Lee, H.C.,Hao, Q. (deposition date: 2008-11-07, release date: 2008-11-18, Last modification date: 2023-11-01)
Primary citation	Liu, Q.,Graeff, R.,Kriksunov, I.A.,Lam, C.M.C.,Lee, H.C.,Hao, Q. Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium Biochemistry, 47:13966-13973, 2008 Cited by PubMed: 19117080 DOI: 10.1021/bi801642q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation