3ROM
Crystal structure of human CD38 in complex with compound CZ-48
Summary for 3ROM
Entry DOI | 10.2210/pdb3rom/pdb |
Related | 1YH3 3ROK 3ROP 3ROQ |
Descriptor | ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-thiophosphono-alpha-D-arabinofuranose (3 entities in total) |
Functional Keywords | cd38, adp-ribosyl cyclase, cyclic adp-ribose, x-crystallography, calcium signaling, inhibitory compound, covalent intermediate, cz-48, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type II membrane protein: P28907 |
Total number of polymer chains | 2 |
Total formula weight | 59575.29 |
Authors | |
Primary citation | Kwong, A.K.,Chen, Z.,Zhang, H.,Leung, F.P.,Lam, C.M.,Ting, K.Y.,Zhang, L.,Hao, Q.,Zhang, L.H.,Lee, H.C. Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry, 51:555-564, 2012 Cited by PubMed: 22142305DOI: 10.1021/bi201509f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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