3ROQ

Crystal structure of human CD38 in complex with compound CZ-46

Summary for 3ROQ

• Entry DOI: 10.2210/pdb3roq/pdb
• Related: 1YH3 3ROK 3ROM 3ROP
• Descriptor: ADP-ribosyl cyclase 1, (2R,3R,4S,5S)-4-fluoro-3,5-dihydroxytetrahydrofuran-2-yl 2-phenylethyl hydrogen (S)-phosphate (3 entities in total)
• Functional Keywords: cd38, adp-ribosyl cyclase, cyclic adp-ribose, calcium signaling, inhibitory compound, covalent intermediate, cz-46, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 59723.40

Authors

Zhang, H.,Lee, H.C.,Hao, Q. (deposition date: 2011-04-26, release date: 2011-12-21, Last modification date: 2023-11-01)

• Primary citation: Kwong, A.K.,Chen, Z.,Zhang, H.,Leung, F.P.,Lam, C.M.,Ting, K.Y.,Zhang, L.,Hao, Q.,Zhang, L.H.,Lee, H.C.; Catalysis-based inhibitors of the calcium signaling function of CD38.; Biochemistry, 51:555-564, 2012; PubMed: 22142305; DOI: 10.1021/bi201509f

Experimental method

X-RAY DIFFRACTION (2.1 Å)