2PGJ

Catalysis associated conformational changes revealed by human cd38 complexed with a non-hydrolyzable substrate analog

Summary for 2PGJ

Related2PGL
DescriptorADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE (3 entities in total)
Functional Keywordswild-type cd38 bound with n1-cidpr, the catalytic pocket, conformational changes of the active site, substrate analog binding, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type II membrane protein P28907
Total number of polymer chains2
Total molecular weight61303.07
Authors
Liu, Q.,Kriksunov, I.A.,Moreau, C.,Graeff, R.,Potter, B.V.L.,Lee, H.C.,Hao, Q. (deposition date: 2007-04-09, release date: 2007-04-24, Last modification date: 2011-07-13)
Primary citation
Liu, Q.,Kriksunov, I.A.,Moreau, C.,Graeff, R.,Potter, B.V.,Lee, H.C.,Hao, Q.
Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog
J.Biol.Chem., 282:24825-24832, 2007
PubMed: 17591784 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M701653200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.71 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.30570.8%3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2pgj.pdb1.gz [47.34 KB])
Coordinate files for Biological unit (2pgj.pdb2.gz [46.72 KB])