3OFS

Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography

Summary for 3OFS

Related3I9M
DescriptorADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (3 entities in total)
Functional Keywordscd38, cyclization, hydrolysis, cadpr, adpr, ara-2'f-nad, ara-2'f-adpr, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type II membrane protein P28907
Total number of polymer chains6
Total molecular weight181800.06
Authors
Zhang, H.,Lee, H.C.,Hao, Q. (deposition date: 2010-08-16, release date: 2010-12-15, Last modification date: 2017-11-08)
Primary citation
Zhang, H.,Graeff, R.,Chen, Z.,Zhang, L.R.,Zhang, L.H.,Lee, H.C.,Hao, Q.
Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal
J.Mol.Biol., 405:1070-1078, 2011
PubMed: 21134381 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2010.11.044
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26460.5%1.7%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3ofs
no rotation
Molmil generated image of 3ofs
rotated about x axis by 90°
Molmil generated image of 3ofs
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3ofs
no rotation
Molmil generated image of 3ofs
rotated about x axis by 90°
Molmil generated image of 3ofs
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3ofs.pdb6.gz [85.8 KB])
Coordinate files for Biological unit (3ofs.pdb4.gz [85.63 KB])
Coordinate files for Biological unit (3ofs.pdb2.gz [85.7 KB])
Coordinate files for Biological unit (3ofs.pdb5.gz [86.5 KB])
Coordinate files for Biological unit (3ofs.pdb3.gz [86.79 KB])
Coordinate files for Biological unit (3ofs.pdb1.gz [85.06 KB])