3I9M
Crystal structure of human CD38 complexed with an analog ara-2'F-ADPR
Summary for 3I9M
Entry DOI | 10.2210/pdb3i9m/pdb |
Related | 3I9J 3I9K 3I9L 3I9N |
Descriptor | ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (3 entities in total) |
Functional Keywords | enzyme-analog complex, covalent reaction intermediate, alpha helices rich domain and alpha/beta domain, alternative splicing, diabetes mellitus, disulfide bond, glycoprotein, hydrolase, membrane, nad, polymorphism, receptor, signal-anchor, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type II membrane protein: P28907 |
Total number of polymer chains | 2 |
Total formula weight | 61851.40 |
Authors | Liu, Q.,Graeff, R.,Kriksunov, I.A.,Jiang, H.,Zhang, B.,Oppenheimer, N.,Lin, H.,Potter, B.V.L.,Lee, H.C.,Hao, Q. (deposition date: 2009-07-12, release date: 2009-07-28, Last modification date: 2023-11-01) |
Primary citation | Liu, Q.,Graeff, R.,Kriksunov, I.A.,Jiang, H.,Zhang, B.,Oppenheimer, N.,Lin, H.,Potter, B.V.L.,Lee, H.C.,Hao, Q. Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase J.Biol.Chem., 284:27637-27645, 2009 Cited by PubMed: 19640846DOI: 10.1074/jbc.M109.031005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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