3OFS
Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ADP-ribosyl cyclase 1 | polymer | 257 | 29754.7 | 6 | UniProt (P28907) Pfam (PF02267) | Homo sapiens (human) | CD38, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10 |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate | non-polymer | 545.3 | 6 | Chemie (AVU) | |||
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 392 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 46 - 300 (UniProt: P28907)
| PDB | External Database | Details |
|---|---|---|
| Glu 44 | - | expression tag |
| Phe 45 | - | expression tag |
| Thr 49 | Gln 49 | engineered mutation |
| Asp 100 | Asn 100 | engineered mutation |
| Ala 146 | Glu 146 | engineered mutation |
| Asp 164 | Asn 164 | engineered mutation |
| Asp 209 | Asn 209 | engineered mutation |
| Asp 219 | Asn 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 178528.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3271.8 | |
| All* | Total formula weight | 181800.1 |
