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PDB: 81 件
7DOH
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Crystal Structure of GD-26 Fab in Complex with TD Peptide from Haloarcula Marismortui Bacteriorhodopsin I
分子名称: GD-26 Fab H-chain, GD-26 Fab L-chain, GLY-THR-GLY-ALA-THR-PRO-ALA-ASP-ASP
著者Lee, C.C, Pao, P.J, Wang, A.H.J.
登録日2020-12-14
公開日2021-10-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis of an epitope tagging system derived from Haloarcula marismortui bacteriorhodopsin I D94N and its monoclonal antibody GD-26.
Febs J., 289, 2022
2IJM
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Crystal Structure of Focal Adhesion Kinase Domain with 2 molecules in the Asymmetric Unit Complexed with ADP and ATP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Focal Adhesion Kinase 1
著者Lee, C.C.
登録日2006-09-29
公開日2007-08-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.187 Å)
主引用文献Crystal Structure of Focal Adhesion Kinase Catalytic Domain Complexed with ATP and Novel 7H-Pyrrolo [2,3-d] pyrimidine Inhibitor Scaffolds
To be Published
7C8R
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Complex Structure of SARS-CoV-2 3CL Protease with TG-0203770
分子名称: 3C-like proteinase, ethyl (4R)-4-[[(2S)-4-methyl-2-[[(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoyl]amino]pentanoyl]amino]-5-[(3S)-2-oxidanylidenepyrrolidin-3-yl]pentanoate
著者Lee, C.C, Wang, A.H.J, Kuo, C.J, Liang, P.H.
登録日2020-06-03
公開日2020-06-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Complex Structures and Cellular Activities of the Potent SARS-CoV-2 3CLpro Inhibitors Guiding Drug Discovery Against COVID-19
To Be Published
7CHY
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BU of 7chy by Molmil
Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26
分子名称: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26, light chain of antibody binding fragment of IgG26
著者Lee, C.C, Wang, A.H.J, Kuo, W.C.
登録日2020-07-06
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP.
J.Mol.Biol., 433, 2020
7CHZ
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Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26A
分子名称: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26A, light chain of antibody binding fragment of IgG26A
著者Lee, C.C, Wang, A.H.J, Kuo, W.C.
登録日2020-07-06
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP.
J.Mol.Biol., 433, 2020
6JP7
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Human antibody 32D6 Fab in complex with PEG
分子名称: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, HEXAETHYLENE GLYCOL, immunoglobulin Fab heavy chain, ...
著者Lee, C.C, Ko, T.P, Lin, L.L, Wang, A.H.J.
登録日2019-03-26
公開日2020-02-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.909 Å)
主引用文献Structural basis of polyethylene glycol recognition by antibody.
J.Biomed.Sci., 27, 2020
6JU0
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Mouse antibody 3.3 Fab in complex with PEG
分子名称: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, Fab heavy chain, ...
著者Lee, C.C, Ko, T.P, Lin, L.L, Wang, A.H.J.
登録日2019-04-12
公開日2020-02-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Structural basis of polyethylene glycol recognition by antibody.
J.Biomed.Sci., 27, 2020
6JWC
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Mouse antibody 2B5 Fab in complex with PEG
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, DI(HYDROXYETHYL)ETHER, DODECAETHYLENE GLYCOL, ...
著者Lee, C.C, Ko, T.P, Su, Y.C, Lin, L.L, Roffler, S.R, Wang, A.H.J.
登録日2019-04-19
公開日2020-02-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.297 Å)
主引用文献Structural basis of polyethylene glycol recognition by antibody.
J.Biomed.Sci., 27, 2020
4Z55
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Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378
分子名称: ALK tyrosine kinase receptor, GLYCEROL, N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
著者Lee, C.C, Spraggon, G.
登録日2015-04-02
公開日2016-02-03
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5Z1X
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Crystal Structure of Laccase from Cerrena sp. RSD1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, ...
著者Lee, C.C, Wu, M.H, Ho, T.H, Wang, A.H.J.
登録日2017-12-28
公開日2018-09-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Kinetic analysis and structural studies of a high-efficiency laccase fromCerrenasp. RSD1.
FEBS Open Bio, 8, 2018
6A4K
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Human antibody 32D6 Fab in complex with H1N1 influenza A virus HA1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ...
著者Lee, C.C, Ko, T.P, Lin, L.L, Wang, A.H.J.
登録日2018-06-20
公開日2019-03-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells.
Sci Rep, 9, 2019
5Z22
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BU of 5z22 by Molmil
Crystal Structure of Laccase from Cerrena sp. RSD1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, ...
著者Lee, C.C, Wu, M.H, Ho, T.H, Wang, A.H.J.
登録日2017-12-28
公開日2019-01-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Enhancement of laccase activity by pre-incubation with organic solvents.
Sci Rep, 9, 2019
7N3U
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Crystal structure of human WEE1 kinase domain in complex with ZN-c3
分子名称: 1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, Wee1-like protein kinase
著者Lee, C.C.
登録日2021-06-02
公開日2021-09-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
J.Med.Chem., 64, 2021
8TZN
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BU of 8tzn by Molmil
Crystal structure of 10E8-GT10.2 HIV-1 MPER scaffold in complex with a non-human primate W3-01 Fab
分子名称: 10E8-GT10.2 MPER scaffold, W3-01 Fab Heavy Chain, W3-01 Fab Light Chain
著者Lee, C.C.D, Wilson, I.A.
登録日2023-08-27
公開日2024-06-12
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Nat.Immunol., 25, 2024
8D6Z
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BU of 8d6z by Molmil
Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV91-27
分子名称: Neutralizing antibody COV91-27 heavy chain, Neutralizing antibody COV91-27 light chain, Spike protein S2 fusion peptide
著者Lee, C.C.D, Lin, T.H, Yuan, M, Wilson, I.A.
登録日2022-06-06
公開日2022-07-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Broadly neutralizing antibodies target the coronavirus fusion peptide.
Science, 377, 2022
8DTR
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Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV30-14
分子名称: COV30-14 heavy chain, COV30-14 light chain, Spike protein S2' stem helix peptide
著者Lee, C.C.D, Lin, T.H, Wilson, I.A.
登録日2022-07-26
公開日2022-11-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Cell Host Microbe, 31, 2023
8DTT
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BU of 8dtt by Molmil
Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV93-03
分子名称: COV93-03 heavy chain, COV93-03 light chain, Spike protein S2' stem helix peptide
著者Lee, C.C.D, Lin, T.H, Wilson, I.A.
登録日2022-07-26
公開日2022-11-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Cell Host Microbe, 31, 2023
2DF7
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BU of 2df7 by Molmil
Crystal structure of infectious bursal disease virus VP2 subviral particle
分子名称: CALCIUM ION, CHLORIDE ION, structural polyprotein VP2
著者Ko, T.P, Lee, C.C, Wang, M.Y, Wang, A.H.
登録日2006-02-27
公開日2006-06-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of infectious bursal disease virus VP2 subviral particle at 2.6A resolution: Implications in virion assembly and immunogenicity.
J.Struct.Biol., 155, 2006
6O0B
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BU of 6o0b by Molmil
Structural and Mechanistic Insights into CO2 Activation by Nitrogenase Iron Protein
分子名称: IRON/SULFUR CLUSTER, Nitrogenase iron protein
著者Rettberg, L.A, Stiebritz, M.T, Kang, W, Lee, C.C, Ribbe, M.W, Hu, Y.
登録日2019-02-15
公開日2019-09-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and Mechanistic Insights into CO2Activation by Nitrogenase Iron Protein.
Chemistry, 25, 2019
6NZJ
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Structural Analysis of a Nitrogenase Iron Protein from Methanosarcina acetivorans: Implications for CO2 Capture by a Surface-Exposed [Fe4S4] Cluster
分子名称: IRON/SULFUR CLUSTER, Nitrogenase iron protein, SULFATE ION
著者Rettberg, L.A, Kang, W, Stiebritz, M.T, Hiller, C.J, Lee, C.C, Liedtke, J, Ribbe, M.W, Hu, Y.
登録日2019-02-13
公開日2019-06-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Analysis of a Nitrogenase Iron Protein from Methanosarcina acetivorans: Implications for CO 2 Capture by a Surface-Exposed [Fe 4 S 4 ] Cluster.
Mbio, 10, 2019
2ZU4
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Complex structure of SARS-CoV 3CL protease with TG-0204998
分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-3-[(2,2-dimethylpropanoyl)amino]-L-alanyl-N-[(1R)-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}pentyl]-L-leucinamide
著者Hsu, M.F, Lee, C.C, Wang, A.H.-J.
登録日2008-10-12
公開日2009-01-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
J.Biol.Chem., 284, 2009
2ZU5
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complex structure of SARS-CoV 3CL protease with TG-0205486
分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-threonyl-N-[(1R)-4-cyclopropyl-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}butyl]-L-leucinamide
著者Hsu, M.F, Lee, C.C, Wang, A.H.-J.
登録日2008-10-12
公開日2009-01-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
J.Biol.Chem., 284, 2009
1LM4
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Structure of Peptide Deformylase from Staphylococcus aureus at 1.45 A
分子名称: FE (III) ION, GLYCEROL, peptide deformylase PDF1
著者Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A.
登録日2002-04-30
公開日2003-06-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1LME
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Crystal Structure of Peptide Deformylase from Thermotoga maritima
分子名称: peptide deformylase
著者Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
登録日2002-05-01
公開日2003-06-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1LM6
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Crystal Structure of Peptide Deformylase from Streptococcus pneumoniae
分子名称: FE (III) ION, GLYCEROL, peptide deformylase DEFB
著者Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A.
登録日2002-04-30
公開日2003-06-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003

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