2ZU4

Complex structure of SARS-CoV 3CL protease with TG-0204998

Summary for 2ZU4

• Entry DOI: 10.2210/pdb2zu4/pdb
• Related: 2ZTX 2ZTY 2ZTZ 2ZU1 2ZU2 2ZU3 2ZU5
• Related PRD ID: PRD_000568
• Descriptor: 3C-like proteinase, N-[(benzyloxy)carbonyl]-3-[(2,2-dimethylpropanoyl)amino]-L-alanyl-N-[(1R)-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}pentyl]-L-leucinamide (3 entities in total)
• Functional Keywords: protease-inhibitor complex, hydrolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: SARS coronavirus (SARS-CoV)
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8
• Total number of polymer chains: 1
• Total formula weight: 34492.40

Authors

Hsu, M.F.,Lee, C.C.,Wang, A.H.-J. (deposition date: 2008-10-12, release date: 2009-01-13, Last modification date: 2023-11-01)

• Primary citation: Lee, C.C.,Kuo, C.J.,Ko, T.P.,Hsu, M.F.,Tsui, Y.C.,Chang, S.C.,Yang, S.,Chen, S.J.,Chen, H.C.,Hsu, M.C.,Shih, S.R.,Liang, P.H.,Wang, A.H.-J.; Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds; J.Biol.Chem., 284:7646-7655, 2009; PubMed: 19144641; DOI: 10.1074/jbc.M807947200

Experimental method

X-RAY DIFFRACTION (1.93 Å)